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PMID: 202746 Published · ppublish English Comparative Study Journal Article

Comparison of two viable variants of simian virus 40.

Journal of virology ·Vol. 25 ·No. 1 ·1978-01-00 ·Pages 339-48

Kay AC, Rao GR, Singer MF

Abstract

The DNAs of two viable strains of simian virus 40, 776 and 777, have been compared by using restriction endonucleases. Differences between the two strains were detected at five separate points on the simian virus 40 genome. One of these differences, in the region of DNA coding for the major viral coat protein, was confirmed by tryptic peptide analysis of coat proteins from the two strains. Some physiological differences between the two strains were examined and can, in general, be explained by differences observed between the DNAs of the two strains. In addition, defective variants derived from strain 777 interfere more efficiently with the replication of strain 777 than with the replication of strain 776.

MeSH Terms
DNA Restriction Enzymes/metabolism DNA, Viral/analysis Defective Viruses/growth & development Genes, Viral Genetic Variation Peptides/analysis Simian virus 40/analysis,genetics,growth & development Viral Interference Viral Proteins/analysis,genetics
Chemicals
DNA, Viral Peptides Viral Proteins DNA Restriction Enzymes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kay A C
Rao G R
Singer M F
References (38)
38 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.25.1.339-348.1978
Published
1978-01-00
Pages
339-48
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC353932
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.25.1.339-348.1978 PMC Full Text View journal details
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