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PMID: 20308177 Published · ppublish English Journal Article

varLD: a program for quantifying variation in linkage disequilibrium patterns between populations.

Bioinformatics (Oxford, England) ·Vol. 26 ·No. 9 ·2010-05-01 ·Pages 1269-70

Ong RT, Teo YY

Abstract

Linkage disequilibrium (LD) differences between populations can potentially result in failure to replicate primary signals of trait association in independent genome-wide association studies (GWAS). However, such inter-population LD differences can be leveraged to narrow the search for common causal variants responsible for the association signals observed. The ability to assess and quantify LD variations among populations is thus expected to contribute to both replication and fine-mapping stages of GWAS. The program varLD is available for download from http://www.nus-cme.org.sg/software/varld.html.

MeSH Terms
Blood Coagulation Chromosome Mapping Computational Biology/methods Genetic Variation Genetics, Population Genome-Wide Association Study/methods Haplotypes Humans Linkage Disequilibrium Models, Genetic Polymorphism, Single Nucleotide Programming Languages Software Warfarin/pharmacology
Chemicals
Warfarin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ong Rick Twee-Hee
NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore.
Teo Yik-Ying
Article Info
Journal
Bioinformatics (Oxford, England)
Abbr.
Bioinformatics
ISSN
1367-4811
Published
2010-05-01
Epub
2010-00-22
Pages
1269-70
Language
English
Region
England
NLM ID
9808944
Subset
IM
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