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PMID: 20374406 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Prevalence of neuropsychiatric symptoms and their association with functional limitations in older adults in the United States: the aging, demographics, and memory study.

Journal of the American Geriatrics Society ·Vol. 58 ·No. 2 ·2010-02-00 ·Pages 330-7

Okura T, Plassman BL, Steffens DC, Llewellyn DJ, Potter GG, Langa KM

Abstract

To estimate the prevalence of neuropsychiatric symptoms and examine their association with functional limitations. Cross-sectional analysis. The Aging, Demographics, and Memory Study (ADAMS). A sample of adults aged 71 and older (N=856) drawn from Health and Retirement Study (HRS), a nationally representative cohort of U.S. adults aged 51 and older. The presence of neuropsychiatric symptoms (delusions, hallucinations, agitation, depression, apathy, elation, anxiety, disinhibition, irritation, and aberrant motor behaviors) was identified using the Neuropsychiatric Inventory. A consensus panel in the ADAMS assigned a cognitive category (normal cognition; cognitive impairment, no dementia (CIND); mild, moderate, or severe dementia). Functional limitations, chronic medical conditions, and sociodemographic information were obtained from the HRS and ADAMS. Forty-three percent of individuals with CIND and 58% of those with dementia exhibited at least one neuropsychiatric symptom. Depression was the most common individual symptom in those with normal cognition (12%), CIND (30%), and mild dementia (25%), whereas apathy (42%) and agitation (41%) were most common in those with severe dementia. Individuals with three or more symptoms and one or more clinically significant symptoms had significantly higher odds of having functional limitations. Those with clinically significant depression had higher odds of activity of daily living limitations, and those with clinically significant depression, anxiety, or aberrant motor behaviors had significantly higher odds of instrumental activity of daily living limitations. Neuropsychiatric symptoms are highly prevalent in older adults with CIND and dementia. Of those with cognitive impairment, a greater number of total neuropsychiatric symptoms and some specific individual symptoms are strongly associated with functional limitations.

MeSH Terms
Activities of Daily Living Aged Aged, 80 and over Behavioral Symptoms/epidemiology Cognition Disorders/epidemiology Cross-Sectional Studies Dementia/epidemiology Female Humans Male Mental Disorders/epidemiology Prevalence United States/epidemiology
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Okura Toru
Division of Geriatric Medicine, Department of Internal Medicine, University of Michigan Ann Arbor, Michigan, USA. [email protected]
Plassman Brenda L
Steffens David C
Llewellyn David J
Potter Guy G
Langa Kenneth M
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Article Info
Journal
Journal of the American Geriatrics Society
Abbr.
J Am Geriatr Soc
ISSN
1532-5415
DOI
10.1111/j.1532-5415.2009.02680.x
Email
[email protected]
Published
2010-02-00
Epub
2010-00-26
Pages
330-7
Language
English
Region
United States
NLM ID
7503062
PMCID
PMC2875937
Subset
IM
Grants
NIA NIH HHS · U01 AG009740 · United States
NIA NIH HHS · R01 AG027010-03 · United States
NIMH NIH HHS · K24 MH070027 · United States
NIA NIH HHS · U01 AG09740 · United States
NIA NIH HHS · R01 AG027010 · United States
NIMH NIH HHS · K23 MH087741 · United States
External Links
PubMed source DOI: 10.1111/j.1532-5415.2009.02680.x PMC Full Text View journal details
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