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PMID: 20395968 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

The primary cilium: a signalling centre during vertebrate development.

Nature reviews. Genetics ·Vol. 11 ·No. 5 ·2010-05-00 ·Pages 331-44

Goetz SC, Anderson KV

Abstract

The primary cilium has recently stepped into the spotlight, as a flood of data show that this organelle has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for hedgehog signal transduction. The formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The cilium therefore represents a nexus for signalling pathways during development. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction.

MeSH Terms
Animals Cilia/metabolism Hedgehog Proteins/metabolism Humans Kinesins Signal Transduction Vertebrates/embryology
Chemicals
Hedgehog Proteins Kinesins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Goetz Sarah C
Developmental Biology Program, Sloan-Kettering Institute, New York, New York 10065, USA.
Anderson Kathryn V
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Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0064
DOI
10.1038/nrg2774
Published
2010-05-00
Pages
331-44
Language
English
Region
England
NLM ID
100962779
PMCID
PMC3121168
Subset
IM
Grants
NINDS NIH HHS · R01 NS044385 · United States
NINDS NIH HHS · R01 NS044385-09 · United States
NINDS NIH HHS · NS044385 · United States
External Links
PubMed source DOI: 10.1038/nrg2774 PMC Full Text View journal details
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