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PMID: 20520622 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

A membranous spindle matrix orchestrates cell division.

Nature reviews. Molecular cell biology ·Vol. 11 ·No. 7 ·2010-07-00 ·Pages 529-35

Zheng Y

Abstract

Eukaryotic cell division uses morphologically different forms of mitosis, referred to as open, partially open and closed mitosis, for accurate chromosome segregation and proper partitioning of other cellular components such as endomembranes and cell fate determinants. Recent studies suggest that the spindle matrix provides a conserved strategy to coordinate the segregation of genetic material and the partitioning of the rest of the cellular contents in all three forms of mitosis.

MeSH Terms
Animals Cell Division/genetics,physiology Chromosome Segregation/genetics,physiology Humans Microtubules/genetics,metabolism Models, Biological Spindle Apparatus/genetics,metabolism
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Zheng Yixian
Department of Embryology, Carnegie Institute for Science, Baltimore, Maryland 21218, USA. [email protected]
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Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0080
DOI
10.1038/nrm2919
Email
[email protected]
Published
2010-07-00
Epub
2010-00-03
Pages
529-35
Language
English
Region
England
NLM ID
100962782
PMCID
PMC5474289
Subset
IM
Grants
NIGMS NIH HHS · R01 GM056312 · United States
Howard Hughes Medical Institute · United States
NIGMS NIH HHS · GM056312 · United States
External Links
PubMed source DOI: 10.1038/nrm2919 PMC Full Text View journal details
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