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PMID: 2053591 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Interleukin-4 induces the synthesis and secretion of MCP-1/JE by human endothelial cells.

The American journal of pathology ·Vol. 138 ·No. 6 ·1991-06-00 ·Pages 1315-9

Rollins BJ, Pober JS

Abstract

The authors have demonstrated that human interleukin-4 (IL-4) induces increased expression of the mRNA encoding the monocyte-specific chemoattractant and activator, MCP-1/JE, in human endothelial cells (EC). In addition, treatment of ECs with IL-4 resulted in the synthesis and secretion of MCP-1/JE protein. While IL-4 did not significantly influence the induced expression of MCP-1/JE mRNA by interleukin-1 (IL-1) or tumor necrosis factor, concomitant treatment with IL-4 and IL-1 caused more secretion of MCP-1/JE protein than either cytokine alone. These results suggest that EC-produced MCP-1/JE may mediate some of IL-4's effects on monocyte physiology in vivo, including IL-4's anti-tumor properties.

MeSH Terms
Cells, Cultured Chemokine CCL2 Chemotactic Factors/biosynthesis,genetics,metabolism Endothelium, Vascular/cytology,metabolism Humans Interleukin-1/pharmacology Interleukin-4/pharmacology RNA, Messenger/metabolism Tumor Necrosis Factor-alpha/pharmacology
Chemicals
Chemokine CCL2 Chemotactic Factors Interleukin-1 RNA, Messenger Tumor Necrosis Factor-alpha Interleukin-4
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rollins B J
Division of Medicine, Dana-Farber Cancer Institute, Boston, MA 02115.
Pober J S
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1991-06-00
Pages
1315-9
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1886397
Subset
IM
Grants
NCI NIH HHS · CA53091 · United States
NHLBI NIH HHS · HL36003 · United States
External Links
PubMed source PMC Full Text View journal details
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