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PMID: 20558395 Published · ppublish English Comment Journal Article Research Support, N.I.H., Extramural

Tarenflurbil: mechanisms and myths.

Archives of neurology ·Vol. 67 ·No. 6 ·2010-06-00 ·Pages 750-2

Sano M

Abstract

暂无摘要

Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Sano Mary
Alzheimer Disease Research Center, Department of Psychiatry, Mount Sinai School of Medicine, James J. Peters Veterans Affairs Medical Center, 130 W Kingsbridge Rd, Code 150, Room 1F01, Bronx, NY 10468, USA. [email protected]
References (9)
9 references, click to expand
  1. Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial.
    JAMA. 2009 Dec 16;302(23):2557-64 PMID: 20009055
  2. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
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  3. Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses.
    Nat Neurosci. 2009 Dec;12(12):1567-76 PMID: 19935655
  4. Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease.
    Arch Neurol. 2008 Aug;65(8):1031-8 PMID: 18695053
  5. Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial.
    Lancet Neurol. 2008 Jun;7(6):483-93 PMID: 18450517
  6. Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals.
    Alzheimer Dis Assoc Disord. 2007 Oct-Dec;21(4):292-9 PMID: 18090435
  7. Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease.
    Neurology. 2006 Feb 28;66(4):602-4 PMID: 16505324
  8. NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo.
    J Clin Invest. 2003 Aug;112(3):440-9 PMID: 12897211
  9. A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system.
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Article Info
Journal
Archives of neurology
Abbr.
Arch Neurol
ISSN
1538-3687
DOI
10.1001/archneurol.2010.94
Email
[email protected]
Published
2010-06-00
Pages
750-2
Language
English
Region
United States
NLM ID
0372436
PMCID
PMC3526376
Grants
NIA NIH HHS · P50 AG005138 · United States
NIA NIH HHS · P50 AG005138-21A1 · United States
NIA NIH HHS · 2P50 AG005138-26 · United States
Corrections
CommentOn
PMID: 20009055
External Links
PubMed source DOI: 10.1001/archneurol.2010.94 PMC Full Text
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