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PMID: 20570405 Published · ppublish English Comparative Study Journal Article Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Obesity is linked with lower brain volume in 700 AD and MCI patients.

Neurobiology of aging ·Vol. 31 ·No. 8 ·2010-08-00 ·Pages 1326-39

Ho AJ, Raji CA, Becker JT, Lopez OL, Kuller LH, Hua X, Lee S, Hibar D, Dinov ID, Stein JL, Jack CR, Weiner MW, Toga AW, Thompson PM, Cardiovascular Health Study, ADNI

Abstract

Obesity is associated with lower brain volumes in cognitively normal elderly subjects, but no study has yet investigated the effects of obesity on brain structure in patients with mild cognitive impairment (MCI) or Alzheimer's disease (AD). To determine if higher body mass index (BMI) is associated with brain volume deficits in cognitively impaired elderly subjects, we analyzed brain magnetic resonance imaging (MRI) scans of 700 MCI or AD patients from 2 different cohorts: the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Cardiovascular Health Study-Cognition Study (CHS-CS). Tensor-based morphometry (TBM) was used to create 3-dimensional maps of regional tissue excess or deficits in subjects with MCI (ADNI, n = 399; CHS-CS, n = 77) and AD (ADNI, n = 188; CHS, n = 36). In both AD and MCI groups, higher body mass index was associated with brain volume deficits in frontal, temporal, parietal, and occipital lobes; the atrophic pattern was consistent in both ADNI and CHS populations. Cardiovascular risk factors, especially obesity, should be considered as influencing brain structure in those already afflicted by cognitive impairment and dementia.

MeSH Terms
Aged Aged, 80 and over Alzheimer Disease/complications,pathology,psychology Atrophy Body Mass Index Brain/pathology Cognition Disorders/complications,pathology,psychology Cohort Studies Female Humans Longitudinal Studies Magnetic Resonance Imaging Male Obesity/complications,pathology Organ Size/physiology Prospective Studies Risk Factors
Authors & Affiliations
16 authors, click to expand affiliations / ORCID
Ho April J
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA, United States.
Raji Cyrus A
Becker James T
Lopez Oscar L
Kuller Lewis H
Hua Xue
Lee Suh
Hibar Derrek
Dinov Ivo D
Stein Jason L
Jack Clifford R
Weiner Michael W
Toga Arthur W
Thompson Paul M
Cardiovascular Health Study
ADNI
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Article Info
Journal
Neurobiology of aging
Abbr.
Neurobiol Aging
ISSN
1558-1497
DOI
10.1016/j.neurobiolaging.2010.04.006
Published
2010-08-00
Epub
2010-00-08
Pages
1326-39
Language
English
Region
United States
NLM ID
8100437
PMCID
PMC3197833
Subset
IM
Grants
NIA NIH HHS · K01 AG030514 · United States
NHLBI NIH HHS · N01-HC-85085 · United States
NHLBI NIH HHS · N01-HC-85081 · United States
NIA NIH HHS · R56 AG020098 · United States
NHLBI NIH HHS · N01HC55222 · United States
NHLBI NIH HHS · N01-HC-85082 · United States
NCRR NIH HHS · U54 RR021813 · United States
NHLBI NIH HHS · N01 HC045133 · United States
NHLBI NIH HHS · N01 HC035129 · United States
NHLBI NIH HHS · N01-HC-85084 · United States
NIBIB NIH HHS · R01 EB007813 · United States
NIA NIH HHS · AG15928 · United States
NIA NIH HHS · R01 AG015928 · United States
NHLBI NIH HHS · U01 HL080295 · United States
NIA NIH HHS · U01 AG024904 · United States
NHLBI NIH HHS · N01 HC015103 · United States
NIA NIH HHS · U19 AG010483 · United States
NHLBI NIH HHS · N01-HC-85086 · United States
NHLBI NIH HHS · N01HC85086 · United States
NCRR NIH HHS · U54-RR021813 · United States
NHLBI NIH HHS · N01 HC-55222 · United States
NICHD NIH HHS · R01 HD050735 · United States
NIA NIH HHS · AG05133 · United States
NIBIB NIH HHS · R01 EB008432 · United States
NHLBI NIH HHS · N01-HC-85083 · United States
NHLBI NIH HHS · N01-HC-75150 · United States
NHLBI NIH HHS · N01-HC-85080 · United States
NIA NIH HHS · P50 AG005133 · United States
NIA NIH HHS · R01 AG020098 · United States
NHLBI NIH HHS · N01HC75150 · United States
NHLBI NIH HHS · N01-HC-85079 · United States
NIA NIH HHS · P30 AG010129 · United States
NIBIB NIH HHS · R01 EB008281 · United States
NIA NIH HHS · AG20098 · United States
NHLBI NIH HHS · N01HC85079 · United States
External Links
PubMed source DOI: 10.1016/j.neurobiolaging.2010.04.006 PMC Full Text View journal details
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