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PMID: 20584912 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Clearance of apoptotic cells: implications in health and disease.

The Journal of cell biology ·Vol. 189 ·No. 7 ·2010-06-28 ·Pages 1059-70

Elliott MR, Ravichandran KS

Abstract

Recent advances in defining the molecular signaling pathways that regulate the phagocytosis of apoptotic cells have improved our understanding of this complex and evolutionarily conserved process. Studies in mice and humans suggest that the prompt removal of dying cells is crucial for immune tolerance and tissue homeostasis. Failed or defective clearance has emerged as an important contributing factor to a range of disease processes. This review addresses how specific molecular alterations of engulfment pathways are linked to pathogenic states. A better understanding of the apoptotic cell clearance process in healthy and diseased states could offer new therapeutic strategies.

MeSH Terms
Animals Apoptosis Cells/cytology,immunology Homeostasis Humans Immune Tolerance Phagocytosis Signal Transduction
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Elliott Michael R
Center for Cell Clearance and the Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA.
Ravichandran Kodi S
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
1540-8140
DOI
10.1083/jcb.201004096
Published
2010-06-28
Pages
1059-70
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2894449
Subset
IM
Grants
NIDDK NIH HHS · P30 DK067629 · United States
NIAID NIH HHS · T32 AI007496 · United States
NIAID NIH HHS · T32 AI055432 · United States
External Links
PubMed source DOI: 10.1083/jcb.201004096 PMC Full Text View journal details
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