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PMID: 20613678 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease.

Neuroreport ·Vol. 21 ·No. 12 ·2010-08-23 ·Pages 802-7

Xu C, Wang Z, Fan M, Liu B, Song M, Zhen X, Jiang T, Alzheimer's Disease Neuroimaging Initiative

Abstract

Earlier studies showed that the Val66Met polymorphisms of the brain-derived neurotrophic factor differentially affect gray matter volume and brain region activities. This study used resting positron emission tomography to investigate the relationship between the polymorphisms of Val66Met and the regional cerebral metabolic rate in the brain. We analyzed the positron emission tomography images of 215 patients from the Alzheimer's Disease Neuroimaging Initiative and found significant differences in the parahippocampal gyrus, superior temporal gyrus, prefrontal cortex, and inferior parietal lobule when comparing Met carriers with noncarriers among both the normal controls and those with mild cognitive impairment. For those with Alzheimer's disease, we also found additional differences in the bilateral insula between the carriers and noncarriers.

MeSH Terms

Aged Aged, 80 and over Alzheimer Disease/genetics,metabolism Amino Acid Substitution/genetics Basal Metabolism/genetics Brain/diagnostic imaging,metabolism Brain Mapping/methods Brain-Derived Neurotrophic Factor/chemistry,genetics Cognition Disorders/diagnostic imaging,metabolism Female Genetic Carrier Screening Genetic Predisposition to Disease/genetics Humans Male Methionine/genetics Middle Aged Polymorphism, Single Nucleotide/genetics Positron-Emission Tomography/methods Valine/genetics

Chemicals

Brain-Derived Neurotrophic Factor Methionine Valine

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Xu Cunlu

LIAMA Center for Computational Medicine, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China.

Wang Zhenhua

Fan Ming

Liu Bing

Song Ming

Zhen Xiantong

Jiang Tianzi

Alzheimer's Disease Neuroimaging Initiative

Investigators

231 investigators, click to expand

Weiner Michael

Aisen Paul

Weiner Michael

Aisen Paul

Petersen Ronald

Jack Clifford R

Jagust William

Trojanowki John

Toga Arthur W

Beckett Laurel

Green Robert C

Gamst Anthony

Saykin Andrew J

Morris John

Potter William Z

Green Robert C

Montine Tom

Petersen Ronald

Aisen Paul

Gamst Anthony

Saykin Andrew J

Morris John

Potter William Z

Green Robert C

Montine Tom

Petersen Ronald

Aisen Paul

Gamst Anthony

Thomas Ronald G

Donohue Michael

Walter Sarah

Jack Clifford R

Dale Anders

Bernstein Matthew

Felmlee Joel

Fox Nick

Thompson Paul

Schuff Norbert

Alexander Gene

Jagust William

Bandy Dan

Koeppe Robert A

Foster Norm

Reiman Eric M

Chen Kewei

Mathis Chet

Morris John

Cairns Nigel J

Taylor-Reinwald Lisa

Trojanowki John

Shaw Les

Lee Virginia M-Y

Korecka Magdalena

Toga Arthur W

Crawford Karen

Neu Scott

Beckett Laurel

Harvey Danielle

Gamst Anthony

Kornak John

Saykin Andrew J

Foroud Tatiana M

Potkin Steven

Shen Li

Kachaturian Zaven

Frank Richard

Snyder Peter J

Molchan Susan

Kaye Jeffrey

Dolen Sara

Quinn Joseph

Schneider Lon

Pawluczyk Sonia

Spann Bryan M

Brewer James

Vanderswag Helen

Heidebrink Judith L

Lord Joanne L

Petersen Ronald

Johnson Kris

Doody Rachelle S

Villanueva-Meyer Javier

Chowdhury Munir

Stern Yaakov

Honig Lawrence S

Bell Karen L

Morris John C

Mintun Mark A

Schneider Stacy

Marson Daniel

Griffith Randall

Clark David

Grossman Hillel

Tang Cheuk

Marzloff George

deToledo-Morrell Leyla

Shah Raj C

Duara Ranjan

Varon Daniel

Roberts Peggy

Albert Marilyn S

Kozauer Nicholas

Zerrate Maria

Rusinek Henry

de Leon Mony J

De Santi Susan M

Doraiswamy P Murali

Petrella Jeffrey R

Aiello Marilyn

Arnold Steve

Karlawish Jason H

Wolk David

Smith Charles D

Given Curtis A

Hardy Peter

Lopez Oscar L

Oakley MaryAnn

Simpson Donna M

Ismail M Saleem

Brand Connie

Richard Jennifer

Mulnard Ruth A

Thai Gaby

Mc-Adams-Ortiz Catherine

Diaz-Arrastia Ramon

Martin-Cook Kristen

DeVous Michael

Levey Allan I

Lah James J

Cellar Janet S

Burns Jeffrey M

Anderson Heather S

Laubinger Mary M

Apostolova Liana

Silverman Daniel H S

Lu Po H

Graff-Radford Neill R

Parfitt Francine

Johnson Heather

Farlow Martin

Herring Scott

Hake Ann M

van Dyck Christopher H

MacAvoy Martha G

Benincasa Amanda L

Chertkow Howard

Bergman Howard

Hosein Chris

Black Sandra

Stefanovic Bojana

Caldwell Curtis

Hsiung Ging-Yuek Robin

Feldman Howard

Assaly Michele

Kertesz Andrew

Rogers John

Trost Dick

Bernick Charles

Munic Donna

Wu Chuang-Kuo

Johnson Nancy

Mesulam Marsel

Sadowsky Carl

Martinez Walter

Villena Teresa

Turner Raymond Scott

Johnson Kathleen

Reynolds Brigid

Sperling Reisa A

Rentz Dorene M

Johnson Keith A

Rosen Allyson

Tinklenberg Jared

Ashford Wes

Sabbagh Marwan

Connor Donald

Jacobson Sandra

Killiany Ronald

Norbash Alexander

Nair Anil

Obisesan Thomas O

Jayam-Trouth Annapurni

Wang Paul

Lerner Alan

Hudson Leon

Ogrocki Paula

DeCarli Charles

Fletcher Evan

Carmichael Owen

Kittur Smita

Borrie Michael

Lee T-Y

Bartha Rob

Johnson Sterling

Asthana Sanjay

Carlsson Cynthia M

Potkin Steven G

Preda Adrian

Nguyen Dana

Tariot Pierre

Fleisher Adam

Reeder Stephanie

Bates Vernice

Capote Horacio

Rainka Michelle

Hendin Barry A

Scharre Douglas W

Kataki Maria

Zimmerman Earl A

Celmins Dzintra

Brown Alice D

Pearlson Godfrey

Blank Karen

Anderson Karen

Saykin Andrew J

Santulli Robert B

Englert Jessica

Williamson Jeff D

Sink Kaycee M

Watkins Franklin

Ott Brian R

Stopa Edward

Tremont Geoffrey

Salloway Stephen

Malloy Paul

Correia Stephen

Rosen Howard J

Miller Bruce L

Mintzer Jacobo

Longmire Crystal Flynn

Spicer Kenneth

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Article Info

Journal

Neuroreport

Abbr.

Neuroreport

ISSN

1473-558X

DOI

10.1097/WNR.0b013e32833ccaf4

Published

2010-08-23

Pages

802-7

Language

English

Region

England

NLM ID

9100935

PMCID

PMC2954459

Subset

Grants

NIA NIH HHS · K01 AG030514 · United States

NIA NIH HHS · P30 AG010129 · United States

NIA NIH HHS · U01 AG024904 · United States

NIA NIH HHS · U19 AG010483 · United States

NIA NIH HHS · P30 AG019610 · United States

NIA NIH HHS · P30 AG010129-20 · United States

External Links

PubMed source DOI: 10.1097/WNR.0b013e32833ccaf4 PMC Full Text View journal details

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Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease.

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