Abstract
Diabetes mellitus is characterized by either the inability to produce insulin (type 1 diabetes) or as insensitivity to insulin secreted by the body (type 2 diabetes). In either case, the body is unable to move blood glucose efficiently across cell membranes to be used. This leads to a variety of local and systemic detrimental effects. Current treatments for diabetes focus on exogenous insulin administration and dietary control. Here, we describe a potential cure for diabetes using a cellular therapy to ameliorate symptoms associated with both reduced insulin secretion and insulin sensitivity. Using induced pluripotent stem (iPS) cells, we were able to derive beta-like cells similar to the endogenous insulin-secreting cells in mice. These beta-like cells secreted insulin in response to glucose and corrected a hyperglycemic phenotype in two mouse models of type 1 and 2 diabetes via an iPS cell transplant. Long-term correction of hyperglycemia was achieved, as determined by blood glucose and hemoglobin A1c levels. These data provide an initial proof of principle for potential clinical applications of reprogrammed somatic cells in the treatment of diabetes type 1 or 2.
MeSH Terms
Animals
Blood Glucose/analysis
Cell Differentiation
Cell Transplantation/methods
Cells, Cultured
Diabetes Mellitus, Type 1/complications,surgery
Diabetes Mellitus, Type 2/complications,surgery
Disease Models, Animal
Fluorescent Antibody Technique
Glycated Hemoglobin A/analysis
Green Fluorescent Proteins/genetics,metabolism
Humans
Hyperglycemia/blood,complications,prevention & control
Induced Pluripotent Stem Cells/cytology,metabolism,transplantation
Insulin/analysis,metabolism
Insulin Secretion
Insulin-Secreting Cells/cytology,metabolism,transplantation
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Mice, Nude
Mice, Transgenic
Chemicals
Blood Glucose
Glycated Hemoglobin A
Insulin
Green Fluorescent Proteins
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Alipio Zaida
Division of Laboratory Medicine, Nevada Cancer Institute, Las Vegas, NV 89135, USA.
Liao Wenbin
Roemer Elizabeth J
Waner Milton
Fink Louis M
Ward David C
Ma Yupo
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