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PMID: 20625093 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Telephone assessment of cognitive function in the late-onset Alzheimer's disease family study.

Archives of neurology ·Vol. 67 ·No. 7 ·2010-07-00 ·Pages 855-61

Wilson RS, Leurgans SE, Foroud TM, Sweet RA, Graff-Radford N, Mayeux R, Bennett DA, National Institute on Aging Late-Onset Alzheimer's Disease Family Study Group

Abstract

Administration of cognitive test batteries by telephone has been shown to be a valid and cost-effective means of assessing cognition, but it remains relatively uncommon in epidemiological research. To develop composite cognitive measures and assess how much of the variability in their scores is associated with mode of test administration (ie, in person or by telephone). Cross-sectional cohort study. Late-Onset Alzheimer's Disease Family Study conducted at 18 centers across the United States. A total of 1584 persons, 368 with dementia, from 646 families. Scores on composite measures of memory and cognitive function derived from a battery of 7 performance tests administered in person (69%) or by telephone (31%) by examiners who underwent a structured performance-based training program with annual recertification. Based in part on the results of a factor analysis of the 7 tests, we developed summary measures of working memory, declarative memory, episodic memory, semantic memory, and global cognition. In linear regression analyses, mode of test administration accounted for less than 2% of the variance in the measures. In mixed-effects models, variability in cognitive scores due to center was small relative to variability due to differences between individuals and families. In epidemiologic research on aging and Alzheimer disease, assessment of cognition by telephone has little effect on performance and provides operational flexibility and a means of reducing both costs and missing data.

MeSH Terms
Adult Aged Aged, 80 and over Alzheimer Disease/complications Cognition Disorders/diagnosis,etiology Cross-Sectional Studies Factor Analysis, Statistical Family Health Female Humans Male Middle Aged Neuropsychological Tests Outcome Assessment, Health Care/methods Psychometrics/methods Telephone
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Wilson Robert S
Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL 60612, USA. [email protected]
Leurgans Sue E
Foroud Tatiana M
Sweet Robert A
Graff-Radford Neill
Mayeux Richard
Bennett David A
National Institute on Aging Late-Onset Alzheimer's Disease Family Study Group
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Article Info
Journal
Archives of neurology
Abbr.
Arch Neurol
ISSN
1538-3687
DOI
10.1001/archneurol.2010.129
Email
[email protected]
Published
2010-07-00
Pages
855-61
Language
English
Region
United States
NLM ID
0372436
PMCID
PMC2971664
Subset
IM
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External Links
PubMed source DOI: 10.1001/archneurol.2010.129 PMC Full Text
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