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PMID: 20631176 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Functional connectivity and brain networks in schizophrenia.

Lynall ME, Bassett DS, Kerwin R, McKenna PJ, Kitzbichler M, Muller U, Bullmore E

Abstract

Schizophrenia has often been conceived as a disorder of connectivity between components of large-scale brain networks. We tested this hypothesis by measuring aspects of both functional connectivity and functional network topology derived from resting-state fMRI time series acquired at 72 cerebral regions over 17 min from 15 healthy volunteers (14 male, 1 female) and 12 people diagnosed with schizophrenia (10 male, 2 female). We investigated between-group differences in strength and diversity of functional connectivity in the 0.06-0.125 Hz frequency interval, and some topological properties of undirected graphs constructed from thresholded interregional correlation matrices. In people with schizophrenia, strength of functional connectivity was significantly decreased, whereas diversity of functional connections was increased. Topologically, functional brain networks had reduced clustering and small-worldness, reduced probability of high-degree hubs, and increased robustness in the schizophrenic group. Reduced degree and clustering were locally significant in medial parietal, premotor and cingulate, and right orbitofrontal cortical nodes of functional networks in schizophrenia. Functional connectivity and topological metrics were correlated with each other and with behavioral performance on a verbal fluency task. We conclude that people with schizophrenia tend to have a less strongly integrated, more diverse profile of brain functional connectivity, associated with a less hub-dominated configuration of complex brain functional networks. Alongside these behaviorally disadvantageous differences, however, brain networks in the schizophrenic group also showed a greater robustness to random attack, pointing to a possible benefit of the schizophrenia connectome, if less extremely expressed.

MeSH Terms
Adult Brain/physiopathology Brain Mapping Cognition/physiology Female Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Models, Neurological Nerve Net/physiopathology Neural Pathways/physiopathology Neuropsychological Tests Principal Component Analysis Schizophrenia/physiopathology
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Lynall Mary-Ellen
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom.
Bassett Danielle S
Kerwin Robert
McKenna Peter J
Kitzbichler Manfred
Muller Ulrich
Bullmore Ed
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
Published
2010-07-14
Pages
9477-87
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC2914251
Subset
IM
Grants
NIBIB NIH HHS · R01 EB001518-05 · United States
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