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PMID: 20635395 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

The origin of fibroblasts and mechanism of cardiac fibrosis.

Journal of cellular physiology ·Vol. 225 ·No. 3 ·2010-11-00 ·Pages 631-7

Krenning G, Zeisberg EM, Kalluri R

Abstract

Fibroblasts are at the heart of cardiac function and are the principal determinants of cardiac fibrosis. Nevertheless, cardiac fibroblasts remain poorly characterized in molecular terms. Evidence is evolving that the cardiac fibroblast is a highly heterogenic cell population, and that such heterogeneity is caused by the distinct origins of fibroblasts in the heart. Cardiac fibroblasts can derive either from resident fibroblasts, from endothelial cells via an endothelial-mesenchynmal transition or from bone marrow-derived circulating progenitor cells, monocytes and fibrocytes. Here, we review the function and origin of fibroblasts in cardiac fibrosis.NB. The information given is correct.

MeSH Terms
Animals Cell Lineage Cell Transdifferentiation Coronary Vessels/pathology,physiopathology Endothelial Cells/pathology Excitation Contraction Coupling Extracellular Matrix/metabolism Fibroblasts/metabolism,pathology Fibrosis Heart Diseases/metabolism,pathology,physiopathology Humans Morphogenesis Myocardial Contraction Myocardium/metabolism,pathology Neovascularization, Physiologic Phenotype Signal Transduction Stem Cells/pathology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Krenning Guido
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
Zeisberg Elisabeth M
Kalluri Raghu
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Article Info
Journal
Journal of cellular physiology
Abbr.
J Cell Physiol
ISSN
1097-4652
DOI
10.1002/jcp.22322
Published
2010-11-00
Pages
631-7
Language
English
Region
United States
NLM ID
0050222
PMCID
PMC3098503
Subset
IM
Grants
NIDDK NIH HHS · DK 55001 · United States
NCI NIH HHS · 1K08 CA129204 · United States
NCI NIH HHS · K08 CA129204-03 · United States
NCI NIH HHS · CA 125550 · United States
NCI NIH HHS · R01 CA125550 · United States
NIDDK NIH HHS · R01 DK055001 · United States
NCI NIH HHS · K08 CA129204 · United States
External Links
PubMed source DOI: 10.1002/jcp.22322 PMC Full Text View journal details
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