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PMID: 20663485 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Separate roles of structured and unstructured regions of Y-family DNA polymerases.

Advances in protein chemistry and structural biology ·Vol. 78 ·2009-00-00 ·Pages 99-146

Ohmori H, Hanafusa T, Ohashi E, Vaziri C

Abstract

All organisms have multiple DNA polymerases specialized for translesion DNA synthesis (TLS) on damaged DNA templates. Mammalian TLS DNA polymerases include Pol eta, Pol iota, Pol kappa, and Rev1 (all classified as "Y-family" members) and Pol zeta (a "B-family" member). Y-family DNA polymerases have highly structured catalytic domains; however, some of these proteins adopt different structures when bound to DNA (such as archaeal Dpo4 and human Pol kappa), while others maintain similar structures independently of DNA binding (such as archaeal Dbh and Saccharomyces cerevisiae Pol eta). DNA binding-induced structural conversions of TLS polymerases depend on flexible regions present within the catalytic domains. In contrast, noncatalytic regions of Y-family proteins, which contain multiple domains and motifs for interactions with other proteins, are predicted to be mostly unstructured, except for short regions corresponding to ubiquitin-binding domains. In this review we discuss how the organization of structured and unstructured regions in TLS polymerases is relevant to their regulation and function during lesion bypass.

MeSH Terms
DNA-Directed DNA Polymerase/chemistry,classification,metabolism Protein Binding Protein Conformation
Chemicals
DNA-Directed DNA Polymerase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Ohmori Haruo
Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan.
Hanafusa Tomo
Ohashi Eiji
Vaziri Cyrus
References (135)
135 references, click to expand
  1. Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus.
    Nat Struct Biol. 2001 Nov;8(11):984-9 PMID: 11685247
  2. Crystal structure of the human rad9-hus1-rad1 clamp.
    J Mol Biol. 2009 Jul 17;390(3):490-502 PMID: 19464297
  3. Insights into the cellular role of enigmatic DNA polymerase iota.
    DNA Repair (Amst). 2009 Mar 1;8(3):420-3 PMID: 19162565
  4. Natively unfolded proteins.
    Curr Opin Struct Biol. 2005 Feb;15(1):35-41 PMID: 15718131
  5. Preferential cis-syn thymine dimer bypass by DNA polymerase eta occurs with biased fidelity.
    Nature. 2004 Mar 4;428(6978):97-100 PMID: 14999287
  6. Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta.
    Science. 1999 Feb 12;283(5404):1001-4 PMID: 9974380
  7. Integrating S-phase checkpoint signaling with trans-lesion synthesis of bulky DNA adducts.
    Cell Biochem Biophys. 2007;47(3):392-408 PMID: 17652783
  8. The Saccharomyces cerevisiae rev6-1 mutation, which inhibits both the lesion bypass and the recombination mode of DNA damage tolerance, is an allele of POL30, encoding proliferating cell nuclear antigen.
    Genetics. 2006 Aug;173(4):1983-9 PMID: 16783012
  9. Structural basis for novel interactions between human translesion synthesis polymerases and proliferating cell nuclear antigen.
    J Biol Chem. 2009 Apr 17;284(16):10552-60 PMID: 19208623
  10. Efficient and high fidelity incorporation of dCTP opposite 7,8-dihydro-8-oxodeoxyguanosine by Sulfolobus solfataricus DNA polymerase Dpo4.
    J Biol Chem. 2006 Jan 27;281(4):2358-72 PMID: 16306039
  11. Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase eta.
    Nat Genet. 2000 Aug;25(4):458-61 PMID: 10932195
  12. The mutational specificity of the Dbh lesion bypass polymerase and its implications.
    J Biol Chem. 2002 Aug 2;277(31):28157-66 PMID: 12023283
  13. Comparative analysis of in vivo interactions between Rev1 protein and other Y-family DNA polymerases in animals and yeasts.
    DNA Repair (Amst). 2008 Mar 1;7(3):439-51 PMID: 18242152
  14. A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest.
    Genes Cells. 2006 Jul;11(7):731-44 PMID: 16824193
  15. UmuD'(2)C is an error-prone DNA polymerase, Escherichia coli pol V.
    Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):8919-24 PMID: 10430871
  16. Activation of ubiquitin-dependent DNA damage bypass is mediated by replication protein a.
    Mol Cell. 2008 Mar 14;29(5):625-36 PMID: 18342608
  17. Roles of PCNA-binding and ubiquitin-binding domains in human DNA polymerase eta in translesion DNA synthesis.
    Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17724-9 PMID: 19001268
  18. Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing.
    Nature. 2004 Jul 15;430(6997):377-80 PMID: 15254543
  19. The post-replication repair RAD18 and RAD6 genes are involved in the prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine in Saccharomyces cerevisiae.
    Nucleic Acids Res. 2004 Sep 23;32(17):5003-10 PMID: 15388802
  20. Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis.
    EMBO J. 2003 Dec 15;22(24):6621-30 PMID: 14657033
  21. Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination.
    EMBO J. 2004 Oct 1;23(19):3886-96 PMID: 15359278
  22. What a difference a decade makes: insights into translesion DNA synthesis.
    Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15591-8 PMID: 17898175
  23. Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells.
    Genes Dev. 2001 Jan 15;15(2):158-72 PMID: 11157773
  24. MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes.
    J Exp Med. 2005 Feb 21;201(4):637-45 PMID: 15710654
  25. Targeting of human DNA polymerase iota to the replication machinery via interaction with PCNA.
    Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14256-61 PMID: 11724965
  26. Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks.
    Genes Cells. 2008 Apr;13(4):343-54 PMID: 18363965
  27. Vertebrate DNA damage tolerance requires the C-terminus but not BRCT or transferase domains of REV1.
    Nucleic Acids Res. 2005 Mar 01;33(4):1280-9 PMID: 15741181
  28. Complex formation of yeast Rev1 with DNA polymerase eta.
    Mol Cell Biol. 2007 Dec;27(23):8401-8 PMID: 17875922
  29. Stepwise translocation of Dpo4 polymerase during error-free bypass of an oxoG lesion.
    PLoS Biol. 2006 Jan;4(1):e11 PMID: 16379496
  30. Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner.
    J Biol Chem. 2008 Dec 12;283(50):35173-85 PMID: 18842586
  31. A single domain in human DNA polymerase iota mediates interaction with PCNA: implications for translesion DNA synthesis.
    Mol Cell Biol. 2005 Feb;25(3):1183-90 PMID: 15657443
  32. Multiple pathways for SOS-induced mutagenesis in Escherichia coli: an overexpression of dinB/dinP results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA.
    Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13792-7 PMID: 9391106
  33. Replication across template T/U by human DNA polymerase-iota.
    Structure. 2009 Jul 15;17(7):974-80 PMID: 19604477
  34. Prediction and functional analysis of native disorder in proteins from the three kingdoms of life.
    J Mol Biol. 2004 Mar 26;337(3):635-45 PMID: 15019783
  35. Lesion bypass of N2-ethylguanine by human DNA polymerase iota.
    J Biol Chem. 2009 Jan 16;284(3):1732-40 PMID: 18984581
  36. Role of DNA polymerases eta, iota and zeta in UV resistance and UV-induced mutagenesis in a human cell line.
    DNA Repair (Amst). 2008 Sep 1;7(9):1551-62 PMID: 18586118
  37. PCNA ubiquitination and REV1 define temporally distinct mechanisms for controlling translesion synthesis in the avian cell line DT40.
    Mol Cell. 2008 May 23;30(4):519-29 PMID: 18498753
  38. dinP, a new gene in Escherichia coli, whose product shows similarities to UmuC and its homologues.
    Mutat Res. 1995 Jun;347(1):1-7 PMID: 7596361
  39. Human DNA polymerase kappa encircles DNA: implications for mismatch extension and lesion bypass.
    Mol Cell. 2007 Feb 23;25(4):601-14 PMID: 17317631
  40. poliota, a remarkably error-prone human DNA polymerase.
    Genes Dev. 2000 Jul 1;14(13):1642-50 PMID: 10887158
  41. Mechanisms of accurate translesion synthesis by human DNA polymerase eta.
    EMBO J. 2000 Jun 15;19(12):3100-9 PMID: 10856253
  42. The N-clasp of human DNA polymerase kappa promotes blockage or error-free bypass of adenine- or guanine-benzo[a]pyrenyl lesions.
    Nucleic Acids Res. 2008 Nov;36(20):6571-84 PMID: 18931375
  43. Werner syndrome protein interacts functionally with translesion DNA polymerases.
    Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10394-9 PMID: 17563354
  44. Structure of human DNA polymerase kappa inserting dATP opposite an 8-OxoG DNA lesion.
    PLoS One. 2009 Jun 02;4(6):e5766 PMID: 19492058
  45. Structural insights into the generation of single-base deletions by the Y family DNA polymerase dbh.
    Mol Cell. 2008 Mar 28;29(6):767-79 PMID: 18374650
  46. Characterization of the DNA binding and structural properties of the BRCT region of human replication factor C p140 subunit.
    J Biol Chem. 2006 Feb 17;281(7):4308-17 PMID: 16361700
  47. Crystal structure of a Y-family DNA polymerase in action: a mechanism for error-prone and lesion-bypass replication.
    Cell. 2001 Oct 5;107(1):91-102 PMID: 11595188
  48. Structure of the human Rev1-DNA-dNTP ternary complex.
    J Mol Biol. 2009 Jul 24;390(4):699-709 PMID: 19464298
  49. REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo.
    Mol Cell. 2006 Jul 21;23(2):265-71 PMID: 16857592
  50. Y-family DNA polymerases in mammalian cells.
    Cell Mol Life Sci. 2009 Jul;66(14):2363-81 PMID: 19367366
  51. Identification of a DinB/UmuC homolog in the archeon Sulfolobus solfataricus.
    Mutat Res. 1996 Oct 25;357(1-2):245-53 PMID: 8876701
  52. RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.
    Nature. 2002 Sep 12;419(6903):135-41 PMID: 12226657
  53. Function and structure of inherently disordered proteins.
    Curr Opin Struct Biol. 2008 Dec;18(6):756-64 PMID: 18952168
  54. Crystal structure of a DinB lesion bypass DNA polymerase catalytic fragment reveals a classic polymerase catalytic domain.
    Mol Cell. 2001 Aug;8(2):427-37 PMID: 11545744
  55. Interaction of hREV1 with three human Y-family DNA polymerases.
    Genes Cells. 2004 Jun;9(6):523-31 PMID: 15189446
  56. Co-localization in replication foci and interaction of human Y-family members, DNA polymerase pol eta and REVl protein.
    DNA Repair (Amst). 2004 Nov 2;3(11):1503-14 PMID: 15380106
  57. Complex formation with Rev1 enhances the proficiency of Saccharomyces cerevisiae DNA polymerase zeta for mismatch extension and for extension opposite from DNA lesions.
    Mol Cell Biol. 2006 Dec;26(24):9555-63 PMID: 17030609
  58. Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells.
    Mol Cell Biol. 2009 Jun;29(11):3113-23 PMID: 19332561
  59. Ubiquitin-binding motif of human DNA polymerase eta is required for correct localization.
    Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):E20; author reply E21 PMID: 19240217
  60. Role of human DNA polymerase kappa as an extender in translesion synthesis.
    Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16000-5 PMID: 12444249
  61. A second proliferating cell nuclear antigen loader complex, Ctf18-replication factor C, stimulates DNA polymerase eta activity.
    J Biol Chem. 2007 Jul 20;282(29):20906-14 PMID: 17545166
  62. Novel role for the C terminus of Saccharomyces cerevisiae Rev1 in mediating protein-protein interactions.
    Mol Cell Biol. 2006 Nov;26(21):8173-82 PMID: 16923957
  63. Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitro.
    Nucleic Acids Res. 2000 Nov 1;28(21):4138-46 PMID: 11058110
  64. Evidence for a second function for Saccharomyces cerevisiae Rev1p.
    Mol Microbiol. 2000 Aug;37(3):549-54 PMID: 10931348
  65. Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage.
    Mol Cell Biol. 2006 Dec;26(23):8892-900 PMID: 16982685
  66. trans-Lesion synthesis past bulky benzo[a]pyrene diol epoxide N2-dG and N6-dA lesions catalyzed by DNA bypass polymerases.
    J Biol Chem. 2002 Aug 23;277(34):30488-94 PMID: 12063247
  67. Translesion synthesis across bulky N2-alkyl guanine DNA adducts by human DNA polymerase kappa.
    J Biol Chem. 2006 Jul 28;281(30):21062-21072 PMID: 16751196
  68. DNA polymerases in adaptive immunity.
    Nat Rev Immunol. 2008 Apr;8(4):302-12 PMID: 18340343
  69. Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation.
    Nature. 2003 Sep 11;425(6954):188-91 PMID: 12968183
  70. Human DNA polymerase eta promotes DNA synthesis from strand invasion intermediates of homologous recombination.
    Mol Cell. 2005 Dec 9;20(5):783-92 PMID: 16337601
  71. Cellular functions of DNA polymerase zeta and Rev1 protein.
    Adv Protein Chem. 2004;69:167-203 PMID: 15588843
  72. PCNA binding through a conserved motif.
    Bioessays. 1998 Mar;20(3):195-9 PMID: 9631646
  73. Proliferating cell nuclear antigen-dependent coordination of the biological functions of human DNA polymerase iota.
    J Biol Chem. 2004 Nov 12;279(46):48360-8 PMID: 15342632
  74. Human DNA polymerase iota incorporates dCTP opposite template G via a G.C + Hoogsteen base pair.
    Structure. 2005 Oct;13(10):1569-77 PMID: 16216587
  75. DNA polymerases eta and iota.
    Adv Protein Chem. 2004;69:205-28 PMID: 15588844
  76. Checkpoint activation regulates mutagenic translesion synthesis.
    Genes Dev. 2003 Jan 1;17(1):64-76 PMID: 12514100
  77. Multiple roles of vertebrate REV genes in DNA repair and recombination.
    Mol Cell Biol. 2005 Jul;25(14):6103-11 PMID: 15988022
  78. DNA polymerase kappa is specifically required for recovery from the benzo[a]pyrene-dihydrodiol epoxide (BPDE)-induced S-phase checkpoint.
    J Biol Chem. 2005 Jun 10;280(23):22343-55 PMID: 15817457
  79. Structure of the catalytic core of S. cerevisiae DNA polymerase eta: implications for translesion DNA synthesis.
    Mol Cell. 2001 Aug;8(2):417-26 PMID: 11545743
  80. Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene).
    Biochemistry. 2002 May 14;41(19):6100-6 PMID: 11994005
  81. Mammalian Pol kappa: regulation of its expression and lesion substrates.
    Adv Protein Chem. 2004;69:265-78 PMID: 15588846
  82. An incoming nucleotide imposes an anti to syn conformational change on the templating purine in the human DNA polymerase-iota active site.
    Structure. 2006 Apr;14(4):749-55 PMID: 16615915
  83. Structure of the ubiquitin-binding zinc finger domain of human DNA Y-polymerase eta.
    EMBO Rep. 2007 Mar;8(3):247-51 PMID: 17304240
  84. Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells.
    EMBO J. 2002 Nov 15;21(22):6246-56 PMID: 12426396
  85. Investigating the role of the little finger domain of Y-family DNA polymerases in low fidelity synthesis and translesion replication.
    J Biol Chem. 2004 Jul 30;279(31):32932-40 PMID: 15155753
  86. The relative roles in vivo of Saccharomyces cerevisiae Pol eta, Pol zeta, Rev1 protein and Pol32 in the bypass and mutation induction of an abasic site, T-T (6-4) photoadduct and T-T cis-syn cyclobutane dimer.
    Genetics. 2005 Feb;169(2):575-82 PMID: 15520252
  87. The Y-family of DNA polymerases.
    Mol Cell. 2001 Jul;8(1):7-8 PMID: 11515498
  88. Mechanisms of dCMP transferase reactions catalyzed by mouse Rev1 protein.
    J Biol Chem. 2002 Jan 25;277(4):3040-6 PMID: 11711549
  89. The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanism.
    Genetics. 1997 Dec;147(4):1557-68 PMID: 9409821
  90. Structural and functional elucidation of the mechanism promoting error-prone synthesis by human DNA polymerase kappa opposite the 7,8-dihydro-8-oxo-2'-deoxyguanosine adduct.
    J Biol Chem. 2009 Aug 14;284(33):22467-22480 PMID: 19542228
  91. Analyses of ultraviolet-induced focus formation of hREV1 protein.
    Genes Cells. 2006 Mar;11(3):193-205 PMID: 16483309
  92. Structure and functional implications of the human rad9-hus1-rad1 cell cycle checkpoint complex.
    J Biol Chem. 2009 Jul 31;284(31):20457-61 PMID: 19535328
  93. Hoogsteen base pair formation promotes synthesis opposite the 1,N6-ethenodeoxyadenosine lesion by human DNA polymerase iota.
    Nat Struct Mol Biol. 2006 Jul;13(7):619-25 PMID: 16819516
  94. Deletion of the Saccharomyces cerevisiae gene RAD30 encoding an Escherichia coli DinB homolog confers UV radiation sensitivity and altered mutability.
    Mol Gen Genet. 1998 Apr;257(6):686-92 PMID: 9604893
  95. Crystal structure of the rad9-rad1-hus1 DNA damage checkpoint complex--implications for clamp loading and regulation.
    Mol Cell. 2009 Jun 26;34(6):735-45 PMID: 19446481
  96. The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae.
    J Biol Chem. 2005 Nov 18;280(46):38657-65 PMID: 16169844
  97. Structural insight into recruitment of translesion DNA polymerase Dpo4 to sliding clamp PCNA.
    Mol Microbiol. 2009 Feb;71(3):678-91 PMID: 19054331
  98. Structure and enzymatic properties of a stable complex of the human REV1 and REV7 proteins.
    J Biol Chem. 2003 Apr 4;278(14):12356-60 PMID: 12529368
  99. Deoxycytidyl transferase activity of the human REV1 protein is closely associated with the conserved polymerase domain.
    J Biol Chem. 2001 May 4;276(18):15051-8 PMID: 11278384
  100. PCNA monoubiquitylation and DNA polymerase eta ubiquitin-binding domain are required to prevent 8-oxoguanine-induced mutagenesis in Saccharomyces cerevisiae.
    Nucleic Acids Res. 2009 May;37(8):2549-59 PMID: 19264809
  101. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG.
    Nature. 1991 Jan 31;349(6308):431-4 PMID: 1992344
  102. A single amino acid governs enhanced activity of DinB DNA polymerases on damaged templates.
    Nature. 2006 Jan 12;439(7073):225-8 PMID: 16407906
  103. Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage.
    Mol Cell. 2004 May 21;14(4):491-500 PMID: 15149598
  104. Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity.
    EMBO J. 1999 Jun 15;18(12):3491-501 PMID: 10369688
  105. Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta.
    Science. 2007 Nov 9;318(5852):967-70 PMID: 17991862
  106. Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function.
    Annu Rev Biochem. 2005;74:317-53 PMID: 15952890
  107. Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa.
    Genes Dev. 2000 Jul 1;14(13):1589-94 PMID: 10887153
  108. Send in the clamps: control of DNA translesion synthesis in eukaryotes.
    Mol Cell. 2007 Nov 30;28(4):522-9 PMID: 18042449
  109. Kinetic analysis of translesion synthesis opposite bulky N2- and O6-alkylguanine DNA adducts by human DNA polymerase REV1.
    J Biol Chem. 2008 Aug 29;283(35):23645-55 PMID: 18591245
  110. Error-prone and inefficient replication across 8-hydroxyguanine (8-oxoguanine) in human and mouse ras gene fragments by DNA polymerase kappa.
    Genes Cells. 2005 Jun;10(6):543-50 PMID: 15938713
  111. hRAD30 mutations in the variant form of xeroderma pigmentosum.
    Science. 1999 Jul 9;285(5425):263-5 PMID: 10398605
  112. The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta.
    Nature. 1999 Jun 17;399(6737):700-4 PMID: 10385124
  113. Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice.
    J Exp Med. 2006 Feb 20;203(2):319-23 PMID: 16476771
  114. The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light.
    Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4186-91 PMID: 10760286
  115. The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesis.
    Nucleic Acids Res. 2005 Jan 13;33(1):356-65 PMID: 15653636
  116. Identification of a novel REV1-interacting motif necessary for DNA polymerase kappa function.
    Genes Cells. 2009 Feb;14(2):101-11 PMID: 19170759
  117. Interaction with DNA polymerase eta is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells.
    DNA Repair (Amst). 2009 May 1;8(5):585-99 PMID: 19157994
  118. Crystal structure of the catalytic core of human DNA polymerase kappa.
    Structure. 2004 Aug;12(8):1395-404 PMID: 15296733
  119. Complex formation of yeast Rev1 and Rev7 proteins: a novel role for the polymerase-associated domain.
    Mol Cell Biol. 2005 Nov;25(21):9734-40 PMID: 16227619
  120. Structural basis of error-prone replication and stalling at a thymine base by human DNA polymerase iota.
    EMBO J. 2009 Jun 3;28(11):1644-54 PMID: 19440206
  121. Snapshots of a Y-family DNA polymerase in replication: substrate-induced conformational transitions and implications for fidelity of Dpo4.
    J Mol Biol. 2008 May 30;379(2):317-30 PMID: 18448122
  122. Human DNA polymerase eta activity and translocation is regulated by phosphorylation.
    Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16578-83 PMID: 18946034
  123. Role of single-stranded DNA in targeting REV1 to primer termini.
    J Biol Chem. 2006 Aug 25;281(34):24314-21 PMID: 16803901
  124. Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.
    Science. 2005 Dec 16;310(5755):1821-4 PMID: 16357261
  125. Thymine-thymine dimer bypass by yeast DNA polymerase zeta.
    Science. 1996 Jun 14;272(5268):1646-9 PMID: 8658138
  126. Interactions in the error-prone postreplication repair proteins hREV1, hREV3, and hREV7.
    J Biol Chem. 2001 Sep 21;276(38):35644-51 PMID: 11485998
  127. The mutagenesis protein UmuC is a DNA polymerase activated by UmuD', RecA, and SSB and is specialized for translesion replication.
    J Biol Chem. 1999 Nov 5;274(45):31763-6 PMID: 10542196
  128. The dinB gene encodes a novel E. coli DNA polymerase, DNA pol IV, involved in mutagenesis.
    Mol Cell. 1999 Aug;4(2):281-6 PMID: 10488344
  129. PCNA, the maestro of the replication fork.
    Cell. 2007 May 18;129(4):665-79 PMID: 17512402
  130. Enzymes of evolutionary change.
    Nature. 1999 Oct 28;401(6756):866-7, 869 PMID: 10553899
  131. Localisation of human Y-family DNA polymerase kappa: relationship to PCNA foci.
    J Cell Sci. 2005 Jan 1;118(Pt 1):129-36 PMID: 15601657
  132. Deoxycytidyl transferase activity of yeast REV1 protein.
    Nature. 1996 Aug 22;382(6593):729-31 PMID: 8751446
  133. Polkappa protects mammalian cells against the lethal and mutagenic effects of benzo[a]pyrene.
    Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15548-53 PMID: 12432099
  134. Rev1 employs a novel mechanism of DNA synthesis using a protein template.
    Science. 2005 Sep 30;309(5744):2219-22 PMID: 16195463
  135. Yeast Rev1 protein promotes complex formation of DNA polymerase zeta with Pol32 subunit of DNA polymerase delta.
    Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9631-6 PMID: 19487673
Article Info
Journal
Advances in protein chemistry and structural biology
Abbr.
Adv Protein Chem Struct Biol
ISSN
1876-1631
DOI
10.1016/S1876-1623(08)78004-0
Published
2009-00-00
Epub
2009-00-27
Pages
99-146
Language
English
Region
Netherlands
NLM ID
101497281
PMCID
PMC3103052
Subset
IM
Grants
NIEHS NIH HHS · R01 ES009558 · United States
NIEHS NIH HHS · R01 ES009558-12 · United States
NIEHS NIH HHS · R29 ES009558 · United States
NIEHS NIH HHS · ES09558 · United States
External Links
PubMed source DOI: 10.1016/S1876-1623(08)78004-0 PMC Full Text
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