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PMID: 20679530 Published · ppublish English Comparative Study Journal Article Research Support, N.I.H., Extramural

Neutrophils influence the level of antigen presentation during the immune response to protein antigens in adjuvants.

Journal of immunology (Baltimore, Md. : 1950) ·Vol. 185 ·No. 5 ·2010-09-01 ·Pages 2927-34

Yang CW, Strong BS, Miller MJ, Unanue ER

Abstract

Neutrophils modulated Ag presentation following immunization with Ags in CFA or IFA or alum. The neutrophils had an important negative role in the CD4 T cell and B cell responses to three protein Ags: hen egg white lysozyme, OVA, and listeriolysin O. In their absence (by depleting with Abs for only the first 24 h, or using genetically neutropenic mice), the cellular responses increased several-fold. The CD8 response was not affected or slightly decreased. Competition for Ag between the presenting cells and the neutrophils, as well as an effect on the response to Ag-bearing dendritic cells (DCs), was documented. Neutrophils entered the draining lymph nodes rapidly and for a brief period of several hours, localizing mainly to the marginal sinus and superficial cortex. There they established brief contact with DCs and macrophages. Moreover, neutrophils imprinted on the quality of the subsequent DC-T cell interactions, despite no physical contact with them; by intravital microscopy, the clustering of Ag-specific T cells and DCs was improved in neutropenic mice. Thus, neutrophils are obligate cells that briefly enter sites of immunization and set the level of Ag presentation. A brief depletion may have a considerably positive impact on vaccination.

MeSH Terms
Adjuvants, Immunologic/administration & dosage,physiology Alum Compounds/administration & dosage Amino Acid Sequence Animals Antigen Presentation/genetics,immunology B-Lymphocytes/immunology,metabolism Bacterial Toxins/administration & dosage,immunology,metabolism Cell Movement/genetics,immunology Freund's Adjuvant/administration & dosage,immunology Heat-Shock Proteins/administration & dosage,immunology,metabolism Hemolysin Proteins/administration & dosage,immunology,metabolism Lipids/administration & dosage,immunology Lymph Nodes/immunology,metabolism,pathology Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Molecular Sequence Data Muramidase/administration & dosage,immunology,metabolism Neutrophils/immunology,metabolism,pathology T-Lymphocytes/immunology,metabolism
Chemicals
Adjuvants, Immunologic Alum Compounds Bacterial Toxins Heat-Shock Proteins Hemolysin Proteins Lipids incomplete Freund's adjuvant aluminum sulfate Freund's Adjuvant hen egg lysozyme Muramidase hlyA protein, Listeria monocytogenes
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Yang Chiao-Wen
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Strong Beverly S I
Miller Mark J
Unanue Emil R
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Article Info
Journal
Journal of immunology (Baltimore, Md. : 1950)
Abbr.
J Immunol
ISSN
1550-6606
Published
2010-09-01
Epub
2010-00-02
Pages
2927-34
Language
English
Region
United States
NLM ID
2985117R
PMCID
PMC3509756
Subset
IM
Grants
NIAID NIH HHS · R01 AI022033 · United States
NIAID NIH HHS · R01 AI077600 · United States
NIAID NIH HHS · AI022033 · United States
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