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PMID: 20683477 Published · ppublish English News Research Support, N.I.H., Extramural

A new nuclease member of the FAN club.

Nature structural & molecular biology ·Vol. 17 ·No. 8 ·2010-08-00 ·Pages 926-8

Huang M, D'Andrea AD

Abstract

To cope with the life-threatening crisis of a DNA interstrand cross-link (ICL), human cells must invoke the Fanconi anemia (FA) DNA repair pathway. The FA pathway is a multistep repair process, requiring multiple nucleolytic incisions and translesion DNA synthesis. Recent work from four laboratories has identified a novel FA-associated nuclease, FAN1, that binds directly to monoubiquitinated FANCD2, resolving a decade-long puzzle regarding the function of this FANCD2 modification.

MeSH Terms
Animals DNA Damage DNA Repair Endodeoxyribonucleases Exodeoxyribonucleases/metabolism Fanconi Anemia/enzymology Fanconi Anemia Complementation Group D2 Protein/metabolism Humans Multifunctional Enzymes Proliferating Cell Nuclear Antigen/metabolism Ubiquitination Xenopus
Chemicals
Fanconi Anemia Complementation Group D2 Protein Multifunctional Enzymes Proliferating Cell Nuclear Antigen Endodeoxyribonucleases Exodeoxyribonucleases FAN1 protein, human
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Huang Min
D'Andrea Alan D
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27 references, click to expand
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Article Info
Journal
Nature structural & molecular biology
Abbr.
Nat Struct Mol Biol
ISSN
1545-9985
DOI
10.1038/nsmb0810-926
Published
2010-08-00
Pages
926-8
Language
English
Region
United States
NLM ID
101186374
PMCID
PMC2945811
Subset
IM
Grants
NIDDK NIH HHS · R01 DK043889 · United States
NIDDK NIH HHS · R01 DK043889-18 · United States
NIDDK NIH HHS · R01-DK43889 · United States
External Links
PubMed source DOI: 10.1038/nsmb0810-926 PMC Full Text View journal details
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