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PMID: 2069388 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Synergistic killing of vancomycin-resistant enterococci of classes A, B, and C by combinations of vancomycin, penicillin, and gentamicin.

Antimicrobial agents and chemotherapy ·Vol. 35 ·No. 4 ·1991-04-00 ·Pages 776-9

Shlaes DM, Etter L, Gutmann L

Abstract

Using both high and low inocula for time-kill curves, we examined the antibiotic killing of clinical isolates of glycopeptide-resistant enterococci (Enterococcus faecium, E. faecalis, and E. gallinarum) belonging to phenotypic resistance classes A, B, and C. None were resistant to high levels (greater than 500 mg/liter) of gentamicin. Vancomycin-penicillin-gentamicin resulted in 2 or more logs of killing above that of the most effective two-antibiotic combination for all strains except two of three E. gallinarum (VanC) strains and a constitutive mutant of a VanB strain. This strategy may be useful clinically.

MeSH Terms

Drug Resistance, Microbial Drug Therapy, Combination/pharmacology Gentamicins/pharmacology Microbial Sensitivity Tests Penicillins/pharmacology Streptococcus/drug effects Vancomycin/pharmacology

Chemicals

Gentamicins Penicillins Vancomycin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Shlaes D M

Infectious Diseases Section, Department of Veterans Affairs Medical Center, Cleveland, Ohio.

Etter L

Gutmann L

References (12)

12 references, click to expand

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.35.4.776

Published

1991-04-00

Pages

776-9

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC245099

Subset

External Links

PubMed source DOI: 10.1128/AAC.35.4.776 PMC Full Text View journal details

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Synergistic killing of vancomycin-resistant enterococci of classes A, B, and C by combinations of vancomycin, penicillin, and gentamicin.

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