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PMID: 2071162 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Regulation of T-cell proliferative responses by cells from solid lung tissue of M. tuberculosis-infected mice.

Immunology ·Vol. 73 ·No. 2 ·1991-06-00 ·Pages 173-9

Apt AS, Kramnik IB, Moroz AM

Abstract

We have studied proliferative responses to mycobacterial antigen preparation (PPD) and to non-specific stimuli of interstitial cells from the lungs of Mycobacterium tuberculosis-infected CBA mice. PPD-reactive lymphocytes appeared in the lung wall tissue in the course of chronic infection, but their proliferative capacity was totally inhibited by the lung macrophages. The latter were also able to suppress the proliferation of immune lymph node T cells. The mechanism of suppression clearly had two components, one being infection-specific and the other non-specific. Non-specific suppression was mediated mainly by prostaglandin E(PGE), whereas the specific mechanism showed only a weak influence of PGE and depended on the presence of I-J+ Lyt-2- nylon-wool-adherent cells in the responder population. Interstitial lung T or B lymphocytes were not involved in specific suppression.

MeSH Terms
Animals Cell Division/immunology Female Immune Tolerance/immunology Lung/immunology Macrophages/immunology Mice Mice, Inbred CBA Prostaglandins E/immunology T-Lymphocytes/immunology Tuberculin/immunology Tuberculosis, Pulmonary/immunology
Chemicals
Prostaglandins E Tuberculin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Apt A S
Experimental Immunogenetics Laboratory, Central Institute for Tuberculosis, Moscow, USSR.
Kramnik I B
Moroz A M
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1991-06-00
Pages
173-9
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1384461
Subset
IM
Corrections
ErratumIn
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External Links
PubMed source PMC Full Text View journal details
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