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PMID: 207299 Published · ppublish English Journal Article

A fine structural study of the removal of the effectiveness of benzo-pyrone treatment of lymphoedema by the destruction of the macrophages by silica.

British journal of experimental pathology ·Vol. 59 ·No. 2 ·1978-04-00 ·Pages 116-27

Casley-Smith JR, Földi-Börcsök E, Földi M

Abstract

Macroscopical, light microscopical and electronmicroscopical observations were made of the diaphragm, skin and brain of rats, some of which were treated with intraperitoneal silica for 8 days (after being given it i.v. for 2 days). The diaphragms showed a most remarkable increase in fibroblast activity and fibrosis beneath the peritoneal mesothelium (which was disintegrating). Deep to this there were many disintegrating macrophages, and much oedema and increased protein concentration. Ligation of the cervical lymphatics produced the usual changes of lymphoedema in the skin and brain. This was greatly reduced in the animals treated with a mixture of benzo-pyrones. However, in those animals also treated with silica, the benzo-pyrones had no effect on the amount of oedema or of protein. In all the animals except those treated with silica, lymphoedema was accompanied by considerable numbers of macrophages entering the affected tissues; in those treated with silica, these numbers were greatly reduced.

MeSH Terms
Animals Brain/ultrastructure Cell Count Coumarins/antagonists & inhibitors,therapeutic use Diaphragm/ultrastructure Lymphedema/drug therapy,pathology Macrophages/drug effects,ultrastructure Male Microscopy, Electron Rats Silicon Dioxide/pharmacology Skin/ultrastructure
Chemicals
Coumarins Silicon Dioxide
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Casley-Smith J R
Földi-Börcsök E
Földi M
References (35)
35 references, click to expand
  1. Lymphostatic exophthalmus.
    Angiologica. 1968;5(6):370-1 PMID: 5716208
  2. [Changes of the neck skin following ligation of the cervical lymph ducts].
    Arch Klin Exp Dermatol. 1968;232(4):367-72 PMID: 5678277
  3. New contributions to the anatomical connections of the brain and the lymphatic system.
    Acta Anat (Basel). 1966;64(4):498-505 PMID: 5957959
  4. The ineffectiveness of coumarin treatment on thermal oedema of macrophage-free rats.
    Br J Exp Pathol. 1976 Apr;57(2):170-8 PMID: 178336
  5. Fine structural aspects of the influence of lymphatic blockage on cold injury of the brain and skin, and the effects of benzo-pyrones.
    Arzneimittelforschung. 1977 Feb;27(2):367-78 PMID: 577155
  6. The prelymphatic pathways of the brain as revealed by cervical lymphatic obstruction and the passage of particles.
    Br J Exp Pathol. 1976 Apr;57(2):179-88 PMID: 773400
  7. The use of a tissue tonometer as a diagnostic aid in extremity lymphoedema: a determination of its conservative treatment with benzo-pyrones.
    Lymphology. 1976 Dec;9(4):127-32 PMID: 1011858
  8. An in vitro demonstration of proteolysis by macrophages and its increase with coumarin.
    Experientia. 1975 Mar 15;31(3):271-3 PMID: 1116522
  9. A new instrument for the evaluation fo tissue tonicity in lymphoedema.
    Lymphology. 1976 Mar;9(1):1-5 PMID: 1263567
  10. Collapse of the blood-brain barrier in lymphostatic cerebral hemangiopathy and in triethyltin poisoning.
    Med Exp Int J Exp Med. 1969;19(6):342-50 PMID: 4097380
  11. An examination of the cytotoxic effects of silica on macrophages.
    J Exp Med. 1966 Aug 1;124(2):141-54 PMID: 4288309
  12. Activity of a macrophage factor in collagen formation by silica.
    Nature. 1967 Apr 29;214(5087):521-2 PMID: 4291779
  13. The macrophage in allograft immunity. I. Effects of silica as a specific macrophage toxin.
    J Reticuloendothel Soc. 1968 Apr;5(2):107-20 PMID: 4297093
  14. The intracellular release of lysosomal contents in macrophages that have ingested silica.
    J Histochem Cytochem. 1970 May;18(5):368-71 PMID: 4316297
  15. The in-vitro effects of silica-treated hamster macrophages on collagen production by hamster fibroblasts.
    J Pathol. 1973 Jan;109(1):21-37 PMID: 4352592
  16. The induction of fibrogenesis by silica-treated alveolar macrophages.
    Environ Res. 1973 Dec;6(4):389-94 PMID: 4359035
  17. Pharmacologic effects of flavonoids on blood vessels.
    Angiologica. 1972;9(3-6):355-74 PMID: 4592457
  18. Lymphedema and vitamins.
    Am J Clin Nutr. 1973 Feb;26(2):185-90 PMID: 4703053
  19. Lymphostatic encephalopathy and vitamins.
    Am J Clin Nutr. 1973 Jul;26(7):696-701 PMID: 4714382
  20. [Lymphostasis and vitamins. The role of histiocytes in the pathophysiology of edema].
    Angiologica. 1973;10(2):101-23 PMID: 4721151
  21. Fine structural aspects of lymphoedema in various tissues and the effects of treatment with coumarin and troxerutin.
    Br J Exp Pathol. 1974 Feb;55(1):88-93 PMID: 4835800
  22. Effects on tissue fine structure of variations in colloid osmotic pressure of glutaraldehyde fixatives.
    J Ultrastruct Res. 1970 Jan;30(1):195-208 PMID: 4904253
  23. [Electron microscopic changes in the central nervous system in experimental lymphogenous encephalopathy. III. The changes revealed by electron optics in the central nervous system in pantothenic acid/pyridoxine deficiency].
    Angiologica. 1967;4(5):271-8 PMID: 4951619
  24. Lymphogenic haemangiopathy. "Prelymphatic" pathways in the wall of cerebral and cervical blood vessels.
    Angiologica. 1968;5(4):250-62 PMID: 5699286
  25. Lymphatic drainage of the brain.
    Experientia. 1968 Dec 15;24(12):1283-7 PMID: 5703044
  26. Lymphogenous encephalopathy--lymphostatic cerebral haemangiopathy.
    Acta Med Acad Sci Hung. 1968;25(3):299-308 PMID: 5720861
  27. Lymphostatic cerebral hemangiopathy. Ultrastructural alteraions in bloodcapillaries of the brain after blockade of crical lymph drainage.
    Vasc Surg. 1968 Dec;2(4):214-22 PMID: 5759062
  28. Immunological aspects of silicosis.
    Bibl Tuberc. 1963;17:230-79 PMID: 13997152
  29. ENDOTHELIAL PERMEABILITY. THE PASSAGE OF PARTICLES INTO AND OUT OF DIAPHRAGMATIC LYMPHATICS.
    Q J Exp Physiol Cogn Med Sci. 1964 Oct;49:365-83 PMID: 14223297
  30. [Electron microscopic changes in the central nervous system in experimental lymphogenic encephalopathy. II. Effect of pantothenic acid-vitamin B6 treatment].
    Angiologica. 1967;4(2):88-94 PMID: 6026300
  31. Vitamin P and lymphatics.
    Angiologica. 1972;9(3-6):375-89 PMID: 4669474
  32. [Treatment of acute experimental lymphostatic edema with vitamins, with vitamin-like natural substances and with massage].
    Angiologica. 1971;8(1):31-42 PMID: 5112984
  33. Increased permeability of the blood-brain barrier in lymphostatic encephalopathy.
    Angiologica. 1969;6(5):275-9 PMID: 5344347
  34. Cerebral oedema as a consequence of experimental cervical lymphatic blockage.
    Angiologica. 1968;5(1):55-63 PMID: 5637028
  35. Lymphogenic encephalopathy and brain edema.
    Angiologica. 1968;5(6):372-6 PMID: 5716209
Article Info
Journal
British journal of experimental pathology
Abbr.
Br J Exp Pathol
ISSN
0007-1021
Published
1978-04-00
Pages
116-27
Language
English
Region
England
NLM ID
0372543
PMCID
PMC2041340
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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