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PMID: 2073119 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

In vitro activities of new antimicrobial agents against multiresistant Staphylococcus aureus isolated from septicemic patients during a Belgian national survey from 1983 to 1985.

Antimicrobial agents and chemotherapy ·Vol. 34 ·No. 11 ·1990-11-00 ·Pages 2260-2

Van der Auwera P, Godard C, Denis C, De Maeyer S, Vanhoof R

Abstract

The antimicrobial agents most active against bacteremic isolates of oxacillin-resistant Staphylococcus aureus isolated from 1983 to 1985 were new fluoroquinolones, including PD 117,596 and PD 127,391 (MIC for 90% of isolates [MIC90] in agar, in micrograms per milliliter, 0.1) and temafloxacin, pefloxacin, and ofloxacin (MIC90, 0.4). Other active antimicrobial agents included fusidic acid (MIC90, 0.2) and fosfomycin (MIC90, 12.5). Vancomycin was active against all isolates. Mupirocin was very active (MIC90, 0.4).

MeSH Terms
Anti-Bacterial Agents/pharmacology Belgium Drug Resistance, Microbial Microbial Sensitivity Tests Oxacillin/pharmacology Penicillin Resistance Sepsis/microbiology Staphylococcal Infections/microbiology Staphylococcus aureus/drug effects
Chemicals
Anti-Bacterial Agents Oxacillin
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Van der Auwera P
Institut Pasteur du Brabant, Brussels, Belgium.
Godard C
Denis C
De Maeyer S
Vanhoof R
References (8)
8 references, click to expand
  1. In vitro activities of PD 117,596 and reference antibiotics against 448 clinical bacterial strains.
    Antimicrob Agents Chemother. 1988 Sep;32(9):1450-5 PMID: 3196008
  2. Mechanism of mupirocin transport into sensitive and resistant bacteria.
    Antimicrob Agents Chemother. 1989 Feb;33(2):156-63 PMID: 2497702
  3. Widespread quinolone resistance among methicillin-resistant Staphylococcus aureus isolates in a general hospital.
    Antimicrob Agents Chemother. 1989 Apr;33(4):593-4 PMID: 2729953
  4. Comparative in vitro activity of PD 127,391, a new fluorinated 4-quinolone derivative.
    Antimicrob Agents Chemother. 1988 Aug;32(8):1278-81 PMID: 3142352
  5. Mupirocin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.
    Drugs. 1986 Nov;32(5):425-44 PMID: 3098541
  6. In-vitro activity of two new carbapenems FCE 22101 and CGP 31608 in comparison with imipenem.
    J Antimicrob Chemother. 1987 Aug;20(2):179-89 PMID: 3478328
  7. In vitro activity of PD 127,391, an enhanced-spectrum quinolone.
    Antimicrob Agents Chemother. 1988 Aug;32(8):1251-6 PMID: 3142350
  8. A general survey of antibiotic treatment of staphylococcal septicaemia and endocarditis.
    Scand J Infect Dis Suppl. 1983;41:151-7 PMID: 6589752
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.34.11.2260
Published
1990-11-00
Pages
2260-2
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC172034
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.34.11.2260 PMC Full Text View journal details
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