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PMID: 20811383 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review

The therapeutic potential of carbon monoxide.

Nature reviews. Drug discovery ·Vol. 9 ·No. 9 ·2010-09-00 ·Pages 728-43

Motterlini R, Otterbein LE

Abstract

Carbon monoxide (CO) is increasingly being accepted as a cytoprotective and homeostatic molecule with important signalling capabilities in physiological and pathophysiological situations. The endogenous production of CO occurs through the activity of constitutive (haem oxygenase 2) and inducible (haem oxygenase 1) haem oxygenases, enzymes that are responsible for the catabolism of haem. Through the generation of its products, which in addition to CO includes the bile pigments biliverdin, bilirubin and ferrous iron, the haem oxygenase 1 system also has an obligatory role in the regulation of the stress response and in cell adaptation to injury. This Review provides an overview of the physiology of CO, summarizes the effects of CO gas and CO-releasing molecules in preclinical animal models of cardiovascular disease, inflammatory disorders and organ transplantation, and discusses the development and therapeutic options for the exploitation of this simple gaseous molecule.

MeSH Terms
Animals Carbon Monoxide/metabolism,pharmacology,therapeutic use Cardiovascular Diseases/drug therapy,physiopathology Homeostasis Humans Inflammation/drug therapy,physiopathology Organ Transplantation/methods Signal Transduction
Chemicals
Carbon Monoxide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Motterlini Roberto
Drug Discovery and Development, Italian Institute of Technology, Via Morego 30, Genoa, Italy.
Otterbein Leo E
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Article Info
Journal
Nature reviews. Drug discovery
Abbr.
Nat Rev Drug Discov
ISSN
1474-1784
DOI
10.1038/nrd3228
Published
2010-09-00
Pages
728-43
Language
English
Region
England
NLM ID
101124171
Subset
IM
Grants
NIGMS NIH HHS · 5R01GM088666 · United States
External Links
PubMed source DOI: 10.1038/nrd3228 View journal details
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