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PMID: 20814421 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma.

Nature reviews. Cancer ·Vol. 10 ·No. 10 ·2010-10-00 ·Pages 683-95

Morris JP, Wang SC, Hebrok M

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is characterized by near-universal mutations in KRAS and frequent deregulation of crucial embryonic signalling pathways, including the Hedgehog (Hh) and Wnt-β-catenin cascades. The creation of mouse models that closely resemble the human disease has provided a platform to better understand when and in which cell types these pathways are misregulated during PDAC development. Here we examine the central part that KRAS plays in the biology of PDAC, and how the timing and location of Hh and Wnt-β-catenin signalling dictate the specification and oncogenic properties of PDAC.

MeSH Terms
Animals Carcinoma, Pancreatic Ductal/genetics,pathology Cell Lineage Genes, ras Hedgehog Proteins/genetics,metabolism Humans Pancreatic Neoplasms/genetics,pathology Signal Transduction Wnt Proteins/genetics,metabolism beta Catenin/metabolism
Chemicals
Hedgehog Proteins Wnt Proteins beta Catenin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Morris John P
Diabetes Center, University of California, San Francisco, 513 Parnassus Ave, San Francisco, California 94143, USA.
Wang Sam C
Hebrok Matthias
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Article Info
Journal
Nature reviews. Cancer
Abbr.
Nat Rev Cancer
ISSN
1474-1768
DOI
10.1038/nrc2899
Published
2010-10-00
Epub
2010-00-03
Pages
683-95
Language
English
Region
England
NLM ID
101124168
PMCID
PMC4085546
Subset
IM
Grants
NCI NIH HHS · R01 CA112537 · United States
NCI NIH HHS · CA112537 · United States
PHS HHS · F32 · United States
External Links
PubMed source DOI: 10.1038/nrc2899 PMC Full Text View journal details
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