Finding the tumor copycat: approximating a human cancer.

Nature medicine ·Vol. 16 ·No. 9 ·2010-09-00 ·Pages 976-7

Van Dyke T

Abstract

暂无摘要

MeSH Terms

Adenocarcinoma/mortality,pathology Animals Animals, Genetically Modified Antineoplastic Agents/administration & dosage Carcinoma, Pancreatic Ductal/drug therapy,mortality,pathology Cell Division Deoxycytidine/analogs & derivatives,pharmacokinetics,therapeutic use Disease Models, Animal Mice Neoplasms/pathology

Chemicals

Antineoplastic Agents Deoxycytidine gemcitabine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Van Dyke Terry

Mouse Cancer Genetics Program, Center for Advanced Preclinical Research, National Cancer Institute, Frederick, Maryland, USA. [email protected]

References (8)

8 references, click to expand

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Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.
Science. 2009 Jun 12;324(5933):1457-61 PMID: 19460966
Development trends for new cancer therapeutics and vaccines.
Drug Discov Today. 2008 Jan;13(1-2):30-7 PMID: 18190861
Cytotoxic chemotherapy for pancreatic cancer: Advances to date and future directions.
Drugs. 2006;66(8):1059-72 PMID: 16789792
A paracrine requirement for hedgehog signalling in cancer.
Nature. 2008 Sep 18;455(7211):406-10 PMID: 18754008
Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations.
Cancer Res. 2006 Jan 1;66(1):95-106 PMID: 16397221
GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation.
Genes Dev. 2009 Jan 1;23(1):24-36 PMID: 19136624
Sonic hedgehog promotes desmoplasia in pancreatic cancer.
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Article Info

Journal

Nature medicine

Abbr.

Nat Med

ISSN

1546-170X

DOI

10.1038/nm0910-976

[email protected]

Published

2010-09-00

Pages

976-7

Language

English

Region

United States

NLM ID

9502015

PMCID

PMC3533444

Subset

Grants

Intramural NIH HHS · Z99 CA999999 · United States

External Links

PubMed source DOI: 10.1038/nm0910-976 PMC Full Text View journal details

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Finding the tumor copycat: approximating a human cancer.

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