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PMID: 20853073 Published · ppublish English Journal Article Review

Functional characterization of stem cell activity in the mouse mammary gland.

Stem cell reviews and reports ·Vol. 7 ·No. 2 ·2011-06-00 ·Pages 238-47

Bruno RD, Smith GH

Abstract

Any portion of the mouse mammary gland is capable of recapitulating a clonally derived complete and functional mammary tree upon transplantation into an epithelial divested mammary fat-pad of a recipient host. As such, it is an ideal model tissue for the study somatic stem cell function. This review will outline what is known regarding the function of stem/progenitor cells in the mouse mammary gland, including how progenitor populations can be functionally defined, the evidence for and potential role of selective DNA strand segregation, and the role of the niche in maintaining and controlling stem cell function.

MeSH Terms
Animals Antigens, Differentiation/metabolism Chromosome Segregation Female Mammary Glands, Animal/cytology,metabolism Mice Stem Cell Niche/anatomy & histology,cytology Stem Cells/metabolism
Chemicals
Antigens, Differentiation
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bruno Robert D
Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Bethesda, MD 20892, USA.
Smith Gilbert H
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Article Info
Journal
Stem cell reviews and reports
Abbr.
Stem Cell Rev Rep
ISSN
2629-3277
DOI
10.1007/s12015-010-9191-9
Published
2011-06-00
Pages
238-47
Language
English
Region
United States
NLM ID
101752767
PMCID
PMC3492888
Subset
IM
Grants
Intramural NIH HHS · Z99 CA999999 · United States
External Links
PubMed source DOI: 10.1007/s12015-010-9191-9 PMC Full Text View journal details
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