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PMID: 20864448 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

The Comparative Toxicogenomics Database: update 2011.

Nucleic acids research ·Vol. 39 ·No. Database issue ·2011-01-00 ·Pages D1067-72

Davis AP, King BL, Mockus S, Murphy CG, Saraceni-Richards C, Rosenstein M, Wiegers T, Mattingly CJ

Abstract

The Comparative Toxicogenomics Database (CTD) is a public resource that promotes understanding about the interaction of environmental chemicals with gene products, and their effects on human health. Biocurators at CTD manually curate a triad of chemical-gene, chemical-disease and gene-disease relationships from the literature. These core data are then integrated to construct chemical-gene-disease networks and to predict many novel relationships using different types of associated data. Since 2009, we dramatically increased the content of CTD to 1.4 million chemical-gene-disease data points and added many features, statistical analyses and analytical tools, including GeneComps and ChemComps (to find comparable genes and chemicals that share toxicogenomic profiles), enriched Gene Ontology terms associated with chemicals, statistically ranked chemical-disease inferences, Venn diagram tools to discover overlapping and unique attributes of any set of chemicals, genes or disease, and enhanced gene pathway data content, among other features. Together, this wealth of expanded chemical-gene-disease data continues to help users generate testable hypotheses about the molecular mechanisms of environmental diseases. CTD is freely available at http://ctd.mdibl.org.

MeSH Terms
Databases, Factual Disease/etiology,genetics Environmental Exposure Gene Regulatory Networks Genes Hazardous Substances/toxicity Humans Software Toxicogenetics
Chemicals
Hazardous Substances
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Davis Allan Peter
Department of Bioinformatics, The Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672, USA.
King Benjamin L
Mockus Susan
Murphy Cynthia G
Saraceni-Richards Cynthia
Rosenstein Michael
Wiegers Thomas
Mattingly Carolyn J
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
1362-4962
DOI
10.1093/nar/gkq813
Published
2011-01-00
Epub
2010-00-22
Pages
D1067-72
Language
English
Region
England
NLM ID
0411011
PMCID
PMC3013756
Subset
IM
Grants
NIEHS NIH HHS · R01 ES014065 · United States
NCRR NIH HHS · P20 RR016463 · United States
NIEHS NIH HHS · R01 ES014065-04S1 · United States
External Links
PubMed source DOI: 10.1093/nar/gkq813 PMC Full Text View journal details
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