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PMID: 2087217 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease.

Metabolic brain disease ·Vol. 5 ·No. 4 ·1990-12-00 ·Pages 179-84

Butterworth RF, Besnard AM

Abstract

Activities of thiamine-dependent enzymes [pyruvate dehydrogenase (PDHC), alpha-ketoglutarate dehydrogenase (alpha KGDH), and transketolase (TK)] were measured in autopsied samples of temporal cortex from six patients with Alzheimer's disease and from eight age-matched control subjects who were free from neurological or psychiatric diseases. Times from death to freezing of dissected material at -70 degrees C were matched. Significant decreases in PDHC (decreased by 70%; P less than 0.01), alpha KGDH (decreased by 70%; p less than 0.01), and TK (decreased by 52%; P less than 0.01) were observed in brain tissue from patients with Alzheimer's disease. In contrast, activities of glutamate dehydrogenase were within normal limits. These findings suggest a possible role for alterations of brain thiamine metabolism or utilization in Alzheimer's disease.

MeSH Terms
Aged Aged, 80 and over Alzheimer Disease/enzymology Female Glutamate Dehydrogenase/metabolism Humans Ketoglutarate Dehydrogenase Complex/metabolism Male Middle Aged Pyruvate Dehydrogenase Complex/metabolism Statistics as Topic Temporal Lobe/enzymology Transketolase/metabolism
Chemicals
Pyruvate Dehydrogenase Complex Ketoglutarate Dehydrogenase Complex Glutamate Dehydrogenase Transketolase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Butterworth R F
Laboratory of Neurochemistry, André-Viallet Clinical Research Center, Hôpital St-Luc (University of Montreal), Quebec, Canada.
Besnard A M
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Article Info
Journal
Metabolic brain disease
Abbr.
Metab Brain Dis
ISSN
0885-7490
DOI
10.1007/BF00997071
Published
1990-12-00
Pages
179-84
Language
English
Region
United States
NLM ID
8610370
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00997071 View journal details
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