Metabolic dysfunction in the pathogenesis of pulmonary hypertension.

Pulmonary artery hypertension is characterized by proliferation in the resistance vessels. A recent study in Science Translational Medicine (Sutendra et al., 2010) found that increased fatty acid oxidation and a shift in the glycolysis/glucose oxidation ratio may be central to the pathogenesis of this process, suggesting that these abnormalities comprise novel treatment targets.