Home LiteratureArticle Details
PMID: 209170 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Quelling of spontaneous transmitter release by nerve impulses in low extracellular calcium solutions.

The Journal of physiology ·Vol. 278 ·1978-05-00 ·Pages 491-500

Erulkar SD, Rahamimoff R, Rotshenker S

Abstract

1. The effect of nerve stimulation on spontaneous transmitter release was studied at the frog neuromuscular synapse which was bathed in a solution containing very low extracellular calcium concentration. Conventional methods for intracellular and extracellular recording were used and the pattern of quantal liberation following the nerve stimulus was determined. 2. Stimulation of the motor nerve (at rates between 0.09 and 2Hz) caused a reduction in the frequency of the miniature e.p.p.s in comparison to the prestimulation values. 3. The mean distribution of the time of occurrence of the miniature e.p.p.s during the interstimulus period showed periodic oscillations. 4. The quelling effect of nerve stimulation on transmitter release is explained by the hypothesis that a low [Ca]o a reversed electrochemical gradient for calcium occurs and nerve stimulation causes an increased calcium conductance leading to calcium efflux which in turn temporarily reduces [Ca]i and transmitter release.

MeSH Terms
Action Potentials Animals Anura Calcium/physiology In Vitro Techniques Motor Endplate/physiology Motor Neurons/physiology Rana pipiens Synaptic Transmission
Chemicals
Calcium
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Erulkar S D
Rahamimoff R
Rotshenker S
References (27)
27 references, click to expand
  1. Localization of active spots within the neuromuscular junction of the frog.
    J Physiol. 1956 Jun 28;132(3):630-49 PMID: 13332599
  2. THE EFFECT OF CALCIUM ON ACETYLCHOLINE RELEASE FROM MOTOR NERVE TERMINALS.
    Proc R Soc Lond B Biol Sci. 1965 Feb 16;161:496-503 PMID: 14278410
  3. PROPAGATION OF ELECTRIC ACTIVITY IN MOTOR NERVE TERMINALS.
    Proc R Soc Lond B Biol Sci. 1965 Feb 16;161:453-82 PMID: 14278408
  4. An electrophysiological investigation of mammalian motor nerve terminals.
    J Physiol. 1963 Apr;166:145-67 PMID: 13955375
  5. The nature of the antagonism between calcium and magnesium ions at the neuromuscular junction.
    J Physiol. 1957 Oct 30;138(3):434-44 PMID: 13481883
  6. Changes in end-plate activity produced by presynaptic polarization.
    J Physiol. 1954 Jun 28;124(3):586-604 PMID: 13175201
  7. The effect of calcium ions on the motor end-plate potentials.
    J Physiol. 1952 Apr;116(4):507-15 PMID: 14946716
  8. An analysis of the end-plate potential recorded with an intracellular electrode.
    J Physiol. 1951 Nov 28;115(3):320-70 PMID: 14898516
  9. Delayed release of transmitter at the frog neuromuscular junction.
    J Physiol. 1973 Jan;228(1):241-57 PMID: 4346703
  10. Further study of the role of calcium in synaptic transmission.
    J Physiol. 1970 May;207(3):789-801 PMID: 5499746
  11. Depolarization and calcium entry in squid giant axons.
    J Physiol. 1971 Nov;218(3):709-55 PMID: 5133953
  12. A method for altering the intracellular calcium concentration.
    J Physiol. 1971;217 Suppl:20P-21P PMID: 5571923
  13. Tetanic and post-tetanic rise in frequency of miniature end-plate potentials in low-calcium solutions.
    J Physiol. 1971 Jan;212(1):245-57 PMID: 5545181
  14. The dependence of evoked transmitter release on external calcium ions at very low mean quantal contents.
    J Physiol. 1974 Jul;240(2):255-78 PMID: 4370832
  15. Co-operative action a calcium ions in transmitter release at the neuromuscular junction.
    J Physiol. 1967 Nov;193(2):419-32 PMID: 6065887
  16. On the mechanism by which calcium and magnesium affect the release of transmitter by nerve impulses.
    J Physiol. 1968 May;196(1):75-86 PMID: 4297537
  17. On the mechanism by which calcium and magnesium affect the spontaneous release of transmitter from mammalian motor nerve terminals.
    J Physiol. 1968 Feb;194(2):355-80 PMID: 4295698
  18. A study of synaptic transmission in the absence of nerve impulses.
    J Physiol. 1967 Sep;192(2):407-36 PMID: 4383089
  19. Tetrodotoxin-resistant electric activity in presynaptic terminals.
    J Physiol. 1969 Aug;203(2):459-87 PMID: 4307710
  20. Transport and metabolism of calcium ions in nerve.
    Prog Biophys Mol Biol. 1972;24:177-223 PMID: 4118937
  21. On the role of mitochondria in transmitter release from motor nerve terminals.
    J Physiol. 1975 Jun;248(2):285-306 PMID: 50439
  22. Proceedings: Periodic fluctuations in transmitter release at the frog neuromuscular junction.
    J Physiol. 1976 Mar;256(1):20P-21P PMID: 180282
  23. Transmitter release induced by injection of calcium ions into nerve terminals.
    Proc R Soc Lond B Biol Sci. 1973 Jul 3;183(1073):421-5 PMID: 4147099
  24. Inhibitory action of Ruthenium red on neuromuscular transmission.
    Proc Natl Acad Sci U S A. 1973 Dec;70(12):3613-6 PMID: 4357869
  25. Calcium role in depolarization-secretion coupling: an aequorin study in squid giant synapse.
    Proc Natl Acad Sci U S A. 1975 Jan;72(1):187-90 PMID: 235124
  26. Ionized calcium concentrations in squid axons.
    J Gen Physiol. 1976 Apr;67(4):433-67 PMID: 818340
  27. Reduction in the frequency of miniature end-plate potentials by nerve stimulation in low calcium solutions.
    Brain Res. 1976 Jan 16;101(2):362-5 PMID: 1244979
Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.1978.sp012319
Published
1978-05-00
Pages
491-500
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1282364
Subset
IM
External Links
PubMed source DOI: 10.1113/jphysiol.1978.sp012319 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2