Home LiteratureArticle Details
PMID: 209172 Published · ppublish English Journal Article

Clumping and oscillations in evoked transmitter release at the frog neuromuscular junction.

The Journal of physiology ·Vol. 278 ·1978-05-00 ·Pages 513-23

Meiri H, Rahamimoff R

Abstract

1. Time series analysis of evoked transmitter release was performed at the frog neuromuscular synapse. 2. Clumping of end-plate potentials with similar amplitude was found in the time domain. 3. At low quantal contents periodic oscillations were observed with a period of 14 sec. 4. Clumping and oscillations are phenomena of presynaptic origin. 5. The results are explained on the hypothesis that periodic fluctuations occur in Ca concentration inside the presynaptic nerve terminal.

MeSH Terms
Animals Anura Evoked Potentials In Vitro Techniques Motor Endplate/physiology Neuromuscular Junction/physiology Ranidae Synapses/physiology Synaptic Transmission Time Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Meiri H
Rahamimoff R
References (14)
14 references, click to expand
  1. The end-plate potential in mammalian muscle.
    J Physiol. 1956 Apr 27;132(1):74-91 PMID: 13320373
  2. A further study of the statistical composition on the end-plate potential.
    J Physiol. 1955 Oct 28;130(1):114-22 PMID: 13278890
  3. Quantal components of the end-plate potential.
    J Physiol. 1954 Jun 28;124(3):560-73 PMID: 13175199
  4. Spontaneous subthreshold activity at motor nerve endings.
    J Physiol. 1952 May;117(1):109-28 PMID: 14946732
  5. Changes in the statistics of transmitter release during facilitation.
    J Physiol. 1973 Mar;229(3):787-810 PMID: 4348351
  6. The effects of calcium and magnesium on statistical release parameters at the crayfish neuromuscular junction.
    J Physiol. 1972 Nov;226(3):761-8 PMID: 4404687
  7. The binomial nature of transmitter release at the crayfish neuromuscular junction.
    J Physiol. 1971 Nov;218(3):757-67 PMID: 4332380
  8. A statistical analysis of the release of acetylcholine at newly formed synapses in striated muscle.
    J Physiol. 1974 Apr;238(1):93-107 PMID: 4365809
  9. Frog skeletal muscle fibers: changes in electrical properties after disruption of transverse tubular system.
    Science. 1967 Dec 29;158(3809):1700-1 PMID: 6070028
  10. Effects of physiologic alterations on binomial transmitter release at magnesium-depressed neuromuscular junctions.
    J Physiol. 1976 Jan;254(1):19-37 PMID: 175150
  11. Oscillatory enzymes.
    Annu Rev Biophys Bioeng. 1976;5:449-76 PMID: 182066
  12. Oscillatory systems in mitochondria.
    Biochim Biophys Acta. 1974 Dec 30;346(3-4):245-60 PMID: 4280315
  13. Modulation of transmitter release by calcium ions and nerve impulses.
    Cold Spring Harb Symp Quant Biol. 1976;40:107-16 PMID: 59656
  14. Sustained oscillations of acetylcholine during nerve stimulation.
    Nature. 1974 Dec 6;252(5483):485-6 PMID: 4431473
Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
Published
1978-05-00
Pages
513-23
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1282366
Subset
IM
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]