Home LiteratureArticle Details
PMID: 20944595 Published · ppublish English Journal Article

The NIH Roadmap Epigenomics Mapping Consortium.

Nature biotechnology ·Vol. 28 ·No. 10 ·2010-10-00 ·Pages 1045-8

Bernstein BE, Stamatoyannopoulos JA, Costello JF, Ren B, Milosavljevic A, Meissner A, Kellis M, Marra MA, Beaudet AL, Ecker JR, Farnham PJ, Hirst M, Lander ES, Mikkelsen TS, Thomson JA

Abstract

The NIH Roadmap Epigenomics Mapping Consortium aims to produce a public resource of epigenomic maps for stem cells and primary ex vivo tissues selected to represent the normal counterparts of tissues and organ systems frequently involved in human disease.

MeSH Terms
Cooperative Behavior Epigenomics Genome, Human/genetics Humans National Institutes of Health (U.S.) Reference Standards Stem Cells/metabolism United States
Authors & Affiliations
15 authors, click to expand affiliations / ORCID
Bernstein Bradley E
Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [email protected]
Stamatoyannopoulos John A
Costello Joseph F
Ren Bing
Milosavljevic Aleksandar
Meissner Alexander
Kellis Manolis
Marra Marco A
Beaudet Arthur L
Ecker Joseph R
Farnham Peggy J
Hirst Martin
Lander Eric S
Mikkelsen Tarjei S
Thomson James A
References (30)
30 references, click to expand
  1. Global mapping of protein-DNA interactions in vivo by digital genomic footprinting.
    Nat Methods. 2009 Apr;6(4):283-9 PMID: 19305407
  2. Tackling the epigenome: challenges and opportunities for collaboration.
    Nat Biotechnol. 2010 Oct;28(10):1039-44 PMID: 20944594
  3. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project.
    Nature. 2007 Jun 14;447(7146):799-816 PMID: 17571346
  4. Genetic mapping in human disease.
    Science. 2008 Nov 7;322(5903):881-8 PMID: 18988837
  5. Genome-scale DNA methylation maps of pluripotent and differentiated cells.
    Nature. 2008 Aug 7;454(7205):766-70 PMID: 18600261
  6. Mechanisms of transformation by MLL.
    Crit Rev Eukaryot Gene Expr. 2004;14(4):235-54 PMID: 15663355
  7. Polycomb silencing mechanisms and the management of genomic programmes.
    Nat Rev Genet. 2007 Jan;8(1):9-22 PMID: 17173055
  8. The epigenomics of cancer.
    Cell. 2007 Feb 23;128(4):683-92 PMID: 17320506
  9. Environmental epigenomics and disease susceptibility.
    Nat Rev Genet. 2007 Apr;8(4):253-62 PMID: 17363974
  10. A second generation human haplotype map of over 3.1 million SNPs.
    Nature. 2007 Oct 18;449(7164):851-61 PMID: 17943122
  11. The mammalian epigenome.
    Cell. 2007 Feb 23;128(4):669-81 PMID: 17320505
  12. Noncoding RNAs and gene silencing.
    Cell. 2007 Feb 23;128(4):763-76 PMID: 17320512
  13. DNA methylation landscapes: provocative insights from epigenomics.
    Nat Rev Genet. 2008 Jun;9(6):465-76 PMID: 18463664
  14. DNA methylation profiling of human chromosomes 6, 20 and 22.
    Nat Genet. 2006 Dec;38(12):1378-85 PMID: 17072317
  15. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes.
    Nature. 2010 Jan 21;463(7279):360-3 PMID: 20054297
  16. Prepublication data sharing.
    Nature. 2009 Sep 10;461(7261):168-70 PMID: 19741685
  17. Chromatin modifications and their function.
    Cell. 2007 Feb 23;128(4):693-705 PMID: 17320507
  18. The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome.
    Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14412-7 PMID: 10588719
  19. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells.
    Nature. 2007 Aug 2;448(7153):553-60 PMID: 17603471
  20. Histone deacetylase inhibitors as anti-neoplastic agents.
    Cancer Lett. 2009 Aug 8;280(2):192-200 PMID: 19345475
  21. Human DNA methylomes at base resolution show widespread epigenomic differences.
    Nature. 2009 Nov 19;462(7271):315-22 PMID: 19829295
  22. Nucleosome destabilization in the epigenetic regulation of gene expression.
    Nat Rev Genet. 2008 Jan;9(1):15-26 PMID: 18059368
  23. Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning.
    Nature. 2008 Mar 13;452(7184):215-9 PMID: 18278030
  24. High-resolution profiling of histone methylations in the human genome.
    Cell. 2007 May 18;129(4):823-37 PMID: 17512414
  25. Nuclear organization of the genome and the potential for gene regulation.
    Nature. 2007 May 24;447(7143):413-7 PMID: 17522674
  26. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals.
    Nat Genet. 2003 Mar;33 Suppl:245-54 PMID: 12610534
  27. Heterochromatin and epigenetic control of gene expression.
    Science. 2003 Aug 8;301(5634):798-802 PMID: 12907790
  28. Histone modifications at human enhancers reflect global cell-type-specific gene expression.
    Nature. 2009 May 7;459(7243):108-12 PMID: 19295514
  29. Perceptions of epigenetics.
    Nature. 2007 May 24;447(7143):396-8 PMID: 17522671
  30. Phenotypic plasticity and the epigenetics of human disease.
    Nature. 2007 May 24;447(7143):433-40 PMID: 17522677
Article Info
Journal
Nature biotechnology
Abbr.
Nat Biotechnol
ISSN
1546-1696
DOI
10.1038/nbt1010-1045
Email
[email protected]
Published
2010-10-00
Pages
1045-8
Language
English
Region
United States
NLM ID
9604648
PMCID
PMC3607281
Subset
IM
Grants
NHGRI NIH HHS · R01 HG003523 · United States
NHGRI NIH HHS · R01 HG004037 · United States
NHGRI NIH HHS · R01 HG005085 · United States
External Links
PubMed source DOI: 10.1038/nbt1010-1045 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2