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PMID: 20967563 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The Generation R Study: design and cohort update 2010.

European journal of epidemiology ·Vol. 25 ·No. 11 ·2010-11-00 ·Pages 823-41

Jaddoe VW, van Duijn CM, van der Heijden AJ, Mackenbach JP, Moll HA, Steegers EA, Tiemeier H, Uitterlinden AG, Verhulst FC, Hofman A

Abstract

The Generation R Study is a population-based prospective cohort study from fetal life until young adulthood. The study is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health during fetal life, childhood and adulthood. The study focuses on four primary areas of research: (1) growth and physical development; (2) behavioural and cognitive development; (3) diseases in childhood; and (4) health and healthcare for pregnant women and children. In total, 9,778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. General follow-up rates until the age of 4 years exceed 75%. Data collection in mothers, fathers and preschool children included questionnaires, detailed physical and ultrasound examinations, behavioural observations, and biological samples. A genome wide association screen is available in the participating children. Regular detailed hands on assessment are performed from the age of 5 years onwards. Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.

MeSH Terms
Adult Child Child Behavior/physiology Child Development/physiology Child, Preschool Cognition Cohort Studies Environmental Exposure/adverse effects Epidemiologic Research Design Female Genetic Diseases, Inborn/genetics Genome-Wide Association Study Health Status Indicators Humans Infant Infant, Newborn Interviews as Topic Male Maternal-Child Health Centers Netherlands/epidemiology Physical Examination/methods Pregnancy Prenatal Care Prospective Studies Surveys and Questionnaires Young Adult
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Jaddoe Vincent W V
The Generation R Study Group (AE006), Erasmus Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. [email protected]
van Duijn Cock M
van der Heijden Albert J
Mackenbach Johan P
Moll Henriëtte A
Steegers Eric A P
Tiemeier Henning
Uitterlinden Andre G
Verhulst Frank C
Hofman Albert
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Article Info
Journal
European journal of epidemiology
Abbr.
Eur J Epidemiol
ISSN
1573-7284
DOI
10.1007/s10654-010-9516-7
Email
[email protected]
Published
2010-11-00
Epub
2010-00-22
Pages
823-41
Language
English
Region
Netherlands
NLM ID
8508062
PMCID
PMC2991548
Subset
IM
External Links
PubMed source DOI: 10.1007/s10654-010-9516-7 PMC Full Text View journal details
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