Megarole for microRNA in muscle disease.

Deregulation of microRNAs in dystrophic muscle highlights their importance in muscle homeostasis. A recent study in Cell Metabolism (Cacchiarelli et al., 2010) shows that the presence of functional dystrophin is required for NO-dependent nitrosylation of the HDAC2 repressor and subsequent activation of a group of microRNAs required for muscle function.