Severity of coronary atherosclerosis related to lipoprotein concentration.
The influence of individual lipoproteins on the severity of coronary atherosclerosis was studied in 41 patients undergoing coronary angiography. The extent of athero-sclerosis was quantified by a coronary atherosclerosis score (CAS) based on the number and severity of lesions in eight proximal segments of the coronary circulation. The concentration of high-density lipoprotein (HDL) showed a strong inverse association with CAS, which was independent of the effects of age and other lipoproteins. On multivariate analysis concentrations of other lipids--namely, total plasma cholesterol, low-density lipoprotein (LDL) cholesterol, and the combined effect of LDL cholesterol plus very-low-density lipoprotein triglyceride--showed direct, significant correlations with CAS, but these were weaker than that of HDL. This study shows that concentrations of several circulating lipoproteins are related to the severity of coronary atherosclerosis, HDL having an apparent retarding effect. These findings may partly explain the influence of lipoproteins on the development of clinical coronary heart disease.
13 references, click to expand
-
Deposition and mobilization of cholesterol ester in cultured human skin fibroblasts.Biochim Biophys Acta. 1976 Dec 20;450(3):367-78 PMID: 1009094
-
Diabetes, blood lipids, and the role of obesity in coronary heart disease risk for women. The Framingham study.Ann Intern Med. 1977 Oct;87(4):393-7 PMID: 199096
-
The Tromsø heart-study. High-density lipoprotein and coronary heart-disease: a prospective case-control study.Lancet. 1977 May 7;1(8019):965-8 PMID: 67464
-
Interaction between high density and low density lipoproteins uptake and degradation by cultured human fibroblasts.J Clin Invest. 1977 Jul;60(1):78-88 PMID: 194923
-
High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study.Am J Med. 1977 May;62(5):707-14 PMID: 193398
-
Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions.J Lipid Res. 1970 Nov;11(6):583-95 PMID: 4100998
-
Canine lipoproteins and atherosclerosis. II. Characterization of the plasma lipoproteins associated with atherogenic and nonatherogenic hyperlipidemia.Circ Res. 1974 Nov;35(5):722-33 PMID: 4138629
-
Ischaemic heart-disease in relation to fasting values of plasma triglycerides and cholesterol. Stockholm prospective study.Lancet. 1972 Apr 22;1(7756):865-8 PMID: 4111826
-
Relationships between plasma lipoprotein cholesterol concentrations and the pool size and metabolism of cholesterol in man.Atherosclerosis. 1976 May-Jun;23(3):535-47 PMID: 178328
-
Serum lipoproteins and coronary heart disease in a population study of Hawaii Japanese men.N Engl J Med. 1976 Feb 5;294(6):293-8 PMID: 173994
-
Serum lipid levels in angiographically defined coronary artery disease.Ann Intern Med. 1976 Mar;84(3):241-5 PMID: 1259257
-
Selective coronary arteriography. I. A percutaneous transfemoral technic.Radiology. 1967 Nov;89(5):815-24 PMID: 6048074
-
Selective cine coronary arteriography. Correlation with clinical findings in 1,000 patients.Circulation. 1966 Jun;33(6):901-10 PMID: 5942973
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
