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PMID: 2109573 Published · ppublish English Clinical Trial Comparative Study Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

Comparison of ofloxacin and ceftriaxone in the treatment of uncomplicated gonorrhea caused by penicillinase-producing and non-penicillinase-producing strains.

Antimicrobial agents and chemotherapy ·Vol. 34 ·No. 1 ·1990-01-00 ·Pages 148-9

Covino JM, Cummings M, Smith B, Benes S, Draft K, McCormack WM

Abstract

Eighty-nine patients with uncomplicated gonorrhea, including 31 patients (34.8%) infected with penicillinase-producing strains of Neisseria gonorrhoeae, were treated with oral ofloxacin (single 400-mg dose) or intramuscular ceftriaxone (250-mg dose). All 47 patients who received ofloxacin and 41 of 42 patients who received ceftriaxone were cured.

MeSH Terms

Adult Ceftriaxone/therapeutic use Chlamydia trachomatis/drug effects Female Gonorrhea/drug therapy,microbiology Humans Male Microbial Sensitivity Tests Neisseria gonorrhoeae/drug effects,enzymology Ofloxacin/therapeutic use Penicillin Resistance Penicillinase/biosynthesis

Chemicals

Ceftriaxone Ofloxacin Penicillinase

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Covino J M

Department of Medicine, State University of New York Health Science Center, Brooklyn.

Cummings M

Smith B

Benes S

Draft K

McCormack W M

References (14)

14 references, click to expand

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.34.1.148

Published

1990-01-00

Pages

148-9

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC171536

Subset

External Links

PubMed source DOI: 10.1128/AAC.34.1.148 PMC Full Text View journal details

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Comparison of ofloxacin and ceftriaxone in the treatment of uncomplicated gonorrhea caused by penicillinase-producing and non-penicillinase-producing strains.

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