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PMID: 21102527 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Synonymous but not the same: the causes and consequences of codon bias.

Nature reviews. Genetics ·Vol. 12 ·No. 1 ·2011-01-00 ·Pages 32-42

Plotkin JB, Kudla G

Abstract

Despite their name, synonymous mutations have significant consequences for cellular processes in all taxa. As a result, an understanding of codon bias is central to fields as diverse as molecular evolution and biotechnology. Although recent advances in sequencing and synthetic biology have helped to resolve longstanding questions about codon bias, they have also uncovered striking patterns that suggest new hypotheses about protein synthesis. Ongoing work to quantify the dynamics of initiation and elongation is as important for understanding natural synonymous variation as it is for designing transgenes in applied contexts.

MeSH Terms
Animals Codon/genetics Drosophila Proteins/genetics Gene Expression Genome Humans Mice Mutation Protein Biosynthesis
Chemicals
Codon Drosophila Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Plotkin Joshua B
Department of Biology and Program in Applied Mathematics and Computational Science, University of Pennsylvania, 433 South University Avenue, Philadelphia, Pennsylvania 19104, USA. [email protected]
Kudla Grzegorz
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Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0064
DOI
10.1038/nrg2899
Email
[email protected]
Published
2011-01-00
Epub
2010-00-23
Pages
32-42
Language
English
Region
England
NLM ID
100962779
PMCID
PMC3074964
Subset
IM
Grants
NIAID NIH HHS · U54 AI057168 · United States
NIAID NIH HHS · U54 AI057168-06S1 · United States
Wellcome Trust · United Kingdom
NIAID NIH HHS · 2U54AI057168 · United States
External Links
PubMed source DOI: 10.1038/nrg2899 PMC Full Text View journal details
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