[The vasodilation and its mechanism of C-type natriuretic peptide].

With routine blood vessel perfusion in vitro, the vasodilation and its mechanism of C-type natriuretic peptide, a new member of natriuretic peptide family were observed in rabbits.,CNP had the dose-dependent vasodilation effects on abdominal artery and celiac vein at the range of 10(-10)-10(-6) mol/L, its action on vein was just like nitroglycerin, its action on artery was weaker than that of ANP. Atropine (10(-7) mol/L), Regitine (20 microg), and indomethacin (20 microg) had nothing effect on the vasodilation of CNP on abdominal artery. But glibenclamide (10(-6) mol/L) and propranolol (10(-6) mol/L) could decrease the vasodilation of CNP obviously, in addition, CNP couldn't inhibit the vasoconstriction of NE.,(1) CNP might be kind of venous systemic vasodilator, and it was also a arterial selective peptide controlling the vessel tone. (2) CNP dilated the vessel at least through two ways: (a) ATP-sensitive K+ channel, (b) beta-receptor.