Chaperoning the SNAREs: a role in preventing neurodegeneration?

Nature cell biology ·Vol. 13 ·No. 1 ·2011-01-00 ·Pages 8-9

Burgoyne RD, Morgan A

Abstract

Despite their potential importance as therapeutic targets, the initial events in neurodegenerative diseases are poorly understood. Emerging evidence suggests that presynaptic dysfunction might be an early event in these pathologies, and three papers now link dysregulation of SNAREprotein levels and function caused by the absence of synuclein or cysteine string protein (CSP) to activity-dependent neurodegeneration.

MeSH Terms

Animals Cells, Cultured HSP40 Heat-Shock Proteins/genetics,metabolism,physiology Membrane Proteins/genetics,metabolism,physiology Mice Mice, Knockout Mice, Transgenic Models, Neurological Neurodegenerative Diseases/genetics,metabolism,physiopathology Neurons/cytology,metabolism,physiology Protein Binding SNARE Proteins/genetics,metabolism Synaptic Transmission/physiology Synaptic Vesicles/metabolism Synaptosomal-Associated Protein 25/genetics,metabolism alpha-Synuclein/genetics,metabolism,physiology

Chemicals

HSP40 Heat-Shock Proteins Membrane Proteins SNARE Proteins Snap25 protein, mouse Synaptosomal-Associated Protein 25 alpha-Synuclein cysteine string protein

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Burgoyne Robert D

Morgan Alan

References (18)

18 references, click to expand

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Article Info

Journal

Nature cell biology

Abbr.

Nat Cell Biol

ISSN

1476-4679

DOI

10.1038/ncb0111-8

Published

2011-01-00

Pages

8-9

Language

English

Region

England

NLM ID

100890575

Subset

Corrections

CommentOn

PMID: 21151134

External Links

PubMed source DOI: 10.1038/ncb0111-8 View journal details

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Chaperoning the SNAREs: a role in preventing neurodegeneration?

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