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PMID: 21238501 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Sex-specificity of associative learning-induced changes in GABAergic tonic inhibition in layer 4 neurons of mouse barrel cortex.

Behavioural brain research ·Vol. 219 ·No. 2 ·2011-06-01 ·Pages 373-7

Urban-Ciecko J, Mozrzymas JW

Abstract

We show that in naïve mice, tonic currents mediated by δ subunit-containing GABA(A) receptors in fast spiking interneurons are larger in females than in males while in regular spiking neurons such a difference was not observed. Moreover, in fast spiking interneurons, associative learning induced a larger reduction of these currents in females than in males. In contrast, in regular spiking neurons, learning similarly enhanced tonic currents in both sexes.

MeSH Terms
Animals Association Learning/physiology Electrophysiological Phenomena Female GABA Agonists/pharmacology GABA Antagonists/pharmacology Interneurons/physiology Isoxazoles/pharmacology Male Mice Neural Conduction/drug effects Neurons/physiology Patch-Clamp Techniques Picrotoxin/pharmacology Receptors, GABA-A/physiology Sex Characteristics Somatosensory Cortex/cytology,drug effects,physiology gamma-Aminobutyric Acid/physiology
Chemicals
GABA Agonists GABA Antagonists Isoxazoles Receptors, GABA-A Picrotoxin gamma-Aminobutyric Acid gaboxadol
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Urban-Ciecko Joanna
Laboratory of Neuroscience, Department of Biophysics, Wroclaw Medical University, ul.Chalubinskiego 3, 50-367 Wroclaw, Poland.
Mozrzymas Jerzy W
Article Info
Journal
Behavioural brain research
Abbr.
Behav Brain Res
ISSN
1872-7549
DOI
10.1016/j.bbr.2011.01.013
Published
2011-06-01
Epub
2011-00-14
Pages
373-7
Language
English
Region
Netherlands
NLM ID
8004872
Subset
IM
External Links
PubMed source DOI: 10.1016/j.bbr.2011.01.013 View journal details
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