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PMID: 21255748 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Reducing case ascertainment costs in U.S. population studies of Alzheimer's disease, dementia, and cognitive impairment-Part 2.

Alzheimer's & dementia : the journal of the Alzheimer's Association ·Vol. 7 ·No. 1 ·2011-01-00 ·Pages 110-23

Evans DA, Grodstein F, Loewenstein D, Kaye J, Weintraub S

Abstract

Dementia of the Alzheimer's type (DAT) is a major public health threat in developed countries where longevity has been extended to the eighth decade of life. Estimates of prevalence and incidence of DAT vary with what is measured, be it change from a baseline cognitive state or a clinical diagnostic endpoint, such as Alzheimer's disease. Judgment of what is psychometrically "normal" at the age of 80 years implicitly condones a decline from what is normal at the age of 30. However, because cognitive aging is very heterogeneous, it is reasonable to ask "Is 'normal for age' good enough to screen for DAT or its earlier precursors of cognitive impairment?" Cost containment and accessibility of ascertainment methods are enhanced by well-validated and reliable methods such as screening for cognitive impairment by telephone interviews. However, focused assessment of episodic memory, the key symptom associated with DAT, might be more effective at distinguishing normal from abnormal cognitive aging trajectories. Alternatively, the futuristic "Smart Home," outfitted with unobtrusive sensors and data storage devices, permits the moment-to-moment recording of activities so that changes that constitute risk for DAT can be identified before the emergence of symptoms.

MeSH Terms
Aging Alzheimer Disease/diagnosis,economics,epidemiology Clinical Trials as Topic Cognition Disorders/diagnosis,economics,epidemiology Community Health Planning Cost-Benefit Analysis Dementia/diagnosis,economics,epidemiology Humans Neuropsychological Tests United States/epidemiology
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Evans Denis A
Rush Institute on Healthy Aging, Rush University Medical Center, Chicago, IL, USA. [email protected]
Grodstein Francine
Loewenstein David
Kaye Jeffrey
Weintraub Sandra
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Article Info
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
Abbr.
Alzheimers Dement
ISSN
1552-5279
DOI
10.1016/j.jalz.2010.11.008
Email
[email protected]
Published
2011-01-00
Pages
110-23
Language
English
Region
United States
NLM ID
101231978
PMCID
PMC3033654
Subset
IM
Grants
NIA NIH HHS · P30 AG013854 · United States
NIA NIH HHS · R01AG024059 · United States
NIA NIH HHS · R01AG024215 · United States
NIA NIH HHS · P30 AG013854-10 · United States
NIA NIH HHS · R01 AG024059 · United States
NIA NIH HHS · P30 AG024978-08 · United States
NIA NIH HHS · P30 AG008017 · United States
NIA NIH HHS · P30AG008017 · United States
NIA NIH HHS · P30AG024978 · United States
NIA NIH HHS · R01 AG024215-05 · United States
NIA NIH HHS · R01AG011101 · United States
NIA NIH HHS · P30 AG008017-15 · United States
NIA NIH HHS · R01 AG024215 · United States
NIA NIH HHS · P30 AG024978 · United States
NIA NIH HHS · R01 AG011101-17 · United States
NIA NIH HHS · R01 AG024059-05 · United States
NIA NIH HHS · P30AG013854 · United States
NIA NIH HHS · R01 AG011101 · United States
External Links
PubMed source DOI: 10.1016/j.jalz.2010.11.008 PMC Full Text View journal details
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