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PMID: 21267408 Published · ppublish English Journal Article

Expression of ErbB4 in the apoptotic neurons of Alzheimer's disease brain.

Anatomy & cell biology ·Vol. 43 ·No. 4 ·2010-12-00 ·Pages 332-9

Woo RS, Lee JH, Yu HN, Song DY, Baik TK

Abstract

Neuregulin-1 (NRG1) signaling participates in the synaptic plasticity, maintenance or regulation of adult brain. Although ErbB4, a key NRG1 receptor, is expressed in multiple regions in the adult animal brain, little is known about its localization in Alzheimer's disease (AD) brains. We previously reported that ErbB4 immunoreactivity showed regional difference in the hippocampus of age-matched control. In the present paper, immunohistochemical characterization of the distribution of ErbB4 receptor in the hippocampus relative to pathology staging were performed in age-matched control (Braak stage 0, n=6) and AD (Braak stage I/V, n=10). Here, we found that ErbB4 immunoreactivity was significantly increased in apoptotic hippocampal pyramidal neurons in the brains of AD patients, compared to those of age-matched control subjects. In AD brains, ErbB4 immunoreactivity was demonstrated to colocalize with the apoptotic signal Bax in apoptotic hippocampal pyramidal neurons. These results suggest that up-regulation of ErbB4 immunoreactivity in apoptotic neuron may involve in the progression of pathology of AD.

Keywords
Alzheimer's disease Apoptosis Bax ErbB4 receptor Neurodegeneration
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Woo Ran-Sook
Department of Anatomy and Neuroscience, College of Medicine, Eulji University, Daejeon, Korea.
Lee Ji-Hye
Yu Ha-Nul
Song Dae-Yong
Baik Tai-Kyoung
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Article Info
Journal
Anatomy & cell biology
Abbr.
Anat Cell Biol
ISSN
2093-3673
DOI
10.5115/acb.2010.43.4.332
Published
2010-12-00
Epub
2010-00-31
Pages
332-9
Language
English
Region
Korea (South)
NLM ID
101531987
PMCID
PMC3026186
External Links
PubMed source DOI: 10.5115/acb.2010.43.4.332 PMC Full Text View journal details
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