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PMID: 2127349 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Neisseria lactamica and Neisseria polysaccharea as possible sources of meningococcal beta-lactam resistance by genetic transformation.

Antimicrobial agents and chemotherapy ·Vol. 34 ·No. 11 ·1990-11-00 ·Pages 2269-72

Saez-Nieto JA, Lujan R, Martinez-Suarez JV, Berron S, Vazquez JA, Viñas M, Campos J

Abstract

We studied the susceptibilities of relatively penicillin G-resistant and -susceptible strains of Neisseria meningitidis, as well as Neisseria lactamica and Neisseria polysaccharea, to penicillin, ampicillin, and several cephalosporins. The MICs of penicillin, ampicillin, cephalothin, and cefuroxime for moderately resistant meningococci have increased two- to sixfold in relation to MICs for susceptible strains. For these strains of meningococci, N. lactamica, and N. polysaccharea, penicillin, ampicillin, cephalothin, and cefuroxime MICs for 50 and 90% of strains were similar. By genetic transformation of a penicillin-susceptible strain of N. meningitidis to low-level penicillin resistance with DNA from penicillin-resistant strains of N. meningitidis, N. lactamica, N. polysaccharea, and N. gonorrhoeae, isogenic strains with the same pattern of resistance to beta-lactams were obtained, suggesting that these commensal Neisseria spp. could be the source of meningococcal resistance genes.

MeSH Terms
Anti-Bacterial Agents/pharmacology DNA, Bacterial/genetics,isolation & purification Drug Resistance, Microbial/genetics Neisseria/genetics Neisseria meningitidis/genetics Penicillin Resistance/genetics Phenotype Transformation, Genetic beta-Lactams
Chemicals
Anti-Bacterial Agents DNA, Bacterial beta-Lactams
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Saez-Nieto J A
Laboratorio de Referencia de Meningococos, Centro Nacional de Microbiologia, Madrid, Spain.
Lujan R
Martinez-Suarez J V
Berron S
Vazquez J A
Viñas M
Campos J
References (13)
13 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.34.11.2269
Published
1990-11-00
Pages
2269-72
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC172037
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.34.11.2269 PMC Full Text View journal details
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