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PMID: 212744 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Isolation, characterization, and synthesis of a corticotropin-inhibiting peptide from human pituitary glands.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 75 ·No. 9 ·1978-09-00 ·Pages 4306-9

Li CH, Chung D, Yamashiro D, Lee CY

Abstract

A corticotropin-inhibiting peptide (CIP) has been isolated from human pituitary extracts. It consists of 32 amino acids with a proposed sequence identical to residues 7--38 of corticotropin (ACTH). The peptide has been synthesized by the solid-phase method. The melanotropic activity of the peptide is estimated to be 30% of the potency of ACTH. It is devoid of corticosteroidogenic activity but is able to inhibit ACTH-stimulated corticosterone production in isolated rat adrenal cells.

MeSH Terms
Adrenocorticotropic Hormone/antagonists & inhibitors Amino Acids/analysis Biological Assay Corticosterone/biosynthesis Humans Melanocytes/drug effects Peptide Fragments/isolation & purification Peptides/chemical synthesis,isolation & purification,pharmacology Pituitary Gland/analysis
Chemicals
Amino Acids Peptide Fragments Peptides Adrenocorticotropic Hormone Corticosterone
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Li C H
Chung D
Yamashiro D
Lee C Y
References (19)
19 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.75.9.4306
Published
1978-09-00
Pages
4306-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC336102
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.75.9.4306 PMC Full Text View journal details
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