Monoamine oxidase and oxidative stress at dopaminergic synapses.

Journal of neural transmission. Supplementum ·Vol. 32 ·1990-00-00 ·Pages 229-38

Cohen G

Abstract

Increased oxidation of dopamine by monoamine oxidase (MAO) in the striatum is associated with an oxidant stress, expressed as a rise in the level of oxidized glutathione. Oxidation of glutathione is suppressed by MAO inhibitors, such as deprenyl and clorgyline. These observations related to Parkinson's disease and to the clinical trial of deprenyl as an agent that may retard progression of the disease.

MeSH Terms

Animals Clorgyline/pharmacology Corpus Striatum/drug effects,metabolism Dopamine/physiology Glutathione/metabolism Glutathione Reductase/metabolism Haloperidol/pharmacology In Vitro Techniques Levodopa/pharmacology Male Mice Monoamine Oxidase/metabolism Oxidation-Reduction Rats Rats, Inbred Strains Reserpine/pharmacology Selegiline/pharmacology Stress, Physiological/metabolism Substantia Nigra/enzymology Synapses/drug effects,metabolism Synaptosomes/drug effects,metabolism

Chemicals

Selegiline Levodopa Reserpine Monoamine Oxidase Glutathione Reductase Glutathione Haloperidol Clorgyline Dopamine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Cohen G

Department of Neurology, Mount Sinai School of Medicine, New York.

Article Info

Journal

Journal of neural transmission. Supplementum

Abbr.

J Neural Transm Suppl

ISSN

0303-6995

DOI

10.1007/978-3-7091-9113-2_33

Published

1990-00-00

Pages

229-38

Language

English

Region

Austria

NLM ID

0425126

Subset

External Links

PubMed source DOI: 10.1007/978-3-7091-9113-2_33 View journal details

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