Abstract
Although several antiviral treatments for HBV infection have recently reached the market, no direct acting antiviral drugs to treat infection with HCV have been licensed in the 20 years since its identification. Excitingly, recent publications herald several small revolutions in antiviral treatment of HCV that have considerable relevance for prospective HCV therapies.
MeSH Terms
Antiviral Agents/therapeutic use
Drug Therapy, Combination
Hepacivirus
Hepatitis C, Chronic/drug therapy
Humans
Interferon alpha-2
Interferon-alpha/therapeutic use
Oligopeptides/therapeutic use
Polyethylene Glycols/therapeutic use
Proline/analogs & derivatives,therapeutic use
Recombinant Proteins
Ribavirin/therapeutic use
Chemicals
Antiviral Agents
Interferon alpha-2
Interferon-alpha
Oligopeptides
Recombinant Proteins
Polyethylene Glycols
Ribavirin
telaprevir
N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide
Proline
peginterferon alfa-2a
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ciesek Sandra
Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Carl-Neuberg-Straβe 1, Hannover, Germany.
Manns Michael P
References (7)
7 references, click to expand
-
Sustained virological response with 29 days of Debio 025 monotherapy in hepatitis C virus genotype 3.
Gut. 2011 Jun;60(6):879
PMID: 20966029
-
Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA.
Science. 2005 Sep 2;309(5740):1577-81
PMID: 16141076
-
Telaprevir for previously treated chronic HCV infection.
N Engl J Med. 2010 Apr 8;362(14):1292-303
PMID: 20375406
-
Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection.
Science. 2010 Jan 8;327(5962):198-201
PMID: 19965718
-
The way forward in HCV treatment--finding the right path.
Nat Rev Drug Discov. 2007 Dec;6(12):991-1000
PMID: 18049473
-
Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial.
Lancet. 2010 Aug 28;376(9742):705-16
PMID: 20692693
-
Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial.
Lancet. 2010 Oct 30;376(9751):1467-75
PMID: 20951424