Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators.

Nature ·Vol. 347 ·No. 6294 ·1990-10-18 ·Pages 645-50

Issemann I, Green S

Abstract

We have cloned a member of the steroid hormone receptor superfamily of ligand-activated transcription factors. The receptor homologue is activated by a diverse class of rodent hepatocarcinogens that causes proliferation of peroxisomes. Identification of a peroxisome proliferator-activated receptor should help elucidate the mechanism of the hypolipidaemic effect of these hepatocarcinogens and aid evaluation of their potential carcinogenic risk to man.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Binding Sites Cloning, Molecular DNA/metabolism Gene Expression/drug effects Humans Hypolipidemic Agents/adverse effects,pharmacology Liver/ultrastructure Liver Neoplasms, Experimental/chemically induced Mice Microbodies/drug effects,ultrastructure Molecular Sequence Data Nafenopin/pharmacology Receptors, Estrogen/genetics,metabolism Receptors, Glucocorticoid/genetics,metabolism Receptors, Steroid/drug effects,genetics,metabolism Sequence Homology, Nucleic Acid Tissue Distribution

Chemicals

Hypolipidemic Agents Receptors, Estrogen Receptors, Glucocorticoid Receptors, Steroid Nafenopin DNA

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Issemann I

Imperial Chemical Industries PLC, Central Toxicology Laboratory, Alderley Park, Macclesfield, UK.

Green S

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/347645a0

Published

1990-10-18

Pages

645-50

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

X57638

Corrections

CommentIn

PMID: 2172828

External Links

PubMed source DOI: 10.1038/347645a0 View journal details

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Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators.

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