The present investigation reports the polymorphism of eight red cell enzymes, studied in 308 unrelated voluntary blood donors from the Rumanian ethnic group of Yugoslavia. Only common phenotypes were detected, which are distributed as in European populations. The estimated gene frequencies were: GLO1*1 = 0.401, GPT*1 = 0.533, PGM1*1 = 0.707, ESD*1 = 0.878, AK1*1 = 0.982, PGD*A = 0.974, ADA*1 = 0.939, ACP1*A = 0.384, ACP1*B = 0.550 and ACP1*C = 0.065. The observed gene frequencies are discussed in the context of other European populations and other populations from Yugoslavia.
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