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PMID: 21353671 Published · ppublish English Clinical Trial Journal Article Research Support, N.I.H., Extramural

Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization.

Fertility and sterility ·Vol. 95 ·No. 6 ·2011-05-00 ·Pages 1970-4

Jungheim ES, Macones GA, Odem RR, Patterson BW, Lanzendorf SE, Ratts VS, Moley KH

Abstract

To determine if follicular free fatty acid (FFA) levels are associated with cumulus oocyte complex (COC) morphology. Prospective cohort study. University in vitro fertilization (IVF) practice. A total of 102 women undergoing IVF. Measurement of FFAs in serum and ovarian follicular fluid. Total and specific follicular and serum FFA levels, correlations between follicular and serum FFAs, and associations between follicular FFA levels and markers of oocyte quality, including COC morphology. Predominant follicular fluid and serum FFAs were oleic, palmitic, linoleic, and stearic acids. Correlations between follicular and serum FFA concentrations were weak (r=0.252, 0.288, 0.236, 0.309, respectively for specific FFAs; r=0.212 for total FFAs). A receiver operating characteristic curve determined total follicular FFAs≥0.232 μmol/mL distinguished women with a lower versus higher percentage of COCs with favorable morphology. Women with elevated follicular FFAs (n=31) were more likely to have COCs with poor morphology than others (n=71; OR 3.3, 95% CI1.2-9.2). This relationship held after adjusting for potential confounders, including age, body mass index, endometriosis, and amount of gonadotropin administered (β=1.2; OR 3.4, 95% CI 1.1-10.4). Elevated follicular FFA levels are associated with poor COC morphology. Further work is needed to determine what factors influence follicular FFA levels and if these factors impact fertility.

MeSH Terms
Adult Cell Shape Cohort Studies Cumulus Cells/cytology Fatty Acids, Nonesterified/analysis,blood,metabolism Female Fertilization in Vitro/methods Follicular Fluid/chemistry,metabolism Humans Infertility/blood,complications,metabolism,therapy Male Obesity/blood,complications,metabolism Oocytes/cytology Ovary/physiology Polycystic Ovary Syndrome/blood,complications,metabolism
Chemicals
Fatty Acids, Nonesterified
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Jungheim Emily S
Department of Obstetrics and Gynecology, Washington University, St. Louis, Missouri 63108, USA. [email protected]
Macones George A
Odem Randall R
Patterson Bruce W
Lanzendorf Susan E
Ratts Valerie S
Moley Kelle H
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Article Info
Journal
Fertility and sterility
Abbr.
Fertil Steril
ISSN
1556-5653
DOI
10.1016/j.fertnstert.2011.01.154
Email
[email protected]
Published
2011-05-00
Epub
2011-00-26
Pages
1970-4
Language
English
Region
United States
NLM ID
0372772
PMCID
PMC3080431
Subset
IM
Grants
NIDDK NIH HHS · P30 DK056341-01 · United States
NICHD NIH HHS · K12 HD063086-01 · United States
NICHD NIH HHS · K12HD063086-01 · United States
NICHD NIH HHS · L50 HD062021 · United States
NICHD NIH HHS · L50 HD062021-01 · United States
NCRR NIH HHS · UL1 RR024992-01 · United States
NICHD NIH HHS · L50HD062021-01 · United States
NICHD NIH HHS · K12 HD063086 · United States
NIDDK NIH HHS · P30 DK056341 · United States
NIDDK NIH HHS · P30DK056341 · United States
NCRR NIH HHS · UL1RR024992 · United States
NCRR NIH HHS · UL1 RR024992 · United States
External Links
PubMed source DOI: 10.1016/j.fertnstert.2011.01.154 PMC Full Text View journal details
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