p53 interacts with p34cdc2 in mammalian cells: implications for cell cycle control and oncogenesis.

Oncogene ·Vol. 5 ·No. 6 ·1990-06-00 ·Pages 795-81

Stürzbecher HW, Maimets T, Chumakov P, Brain R, Addison C, Simanis V, Rudge K, Philp R, Grimaldi M, Court W

Abstract

The p53 gene product has been implicated in both human and animal tumorigenesis. p53 complexes with the transforming proteins encoded by several different DNA tumour viruses. We demonstrate that human p53 is phosphorylated by the mammalian p34cdc2 kinase in vitro and coprecipitates with p34cdc2 in vivo. Our observations suggest that phosphorylation of p53 by p34cdc2 kinase may regulate the known activities of p53 in the initiation steps of DNA replication in mammalian cells.

MeSH Terms

Amino Acid Sequence Animals CDC2 Protein Kinase Cell Cycle/physiology Cell Line DNA Replication/physiology Haplorhini HeLa Cells Humans Molecular Sequence Data Oncogene Proteins/genetics,metabolism Phosphoproteins/genetics,metabolism,physiology Phosphorylation Precipitin Tests Protein Kinases/pharmacology Transfection Tumor Suppressor Protein p53

Chemicals

Oncogene Proteins Phosphoproteins Tumor Suppressor Protein p53 Protein Kinases CDC2 Protein Kinase

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Stürzbecher H W

Cell Proliferation Laboratory, Marie Curie Research Institute, Oxted, Surrey, UK.

Maimets T

Chumakov P

Brain R

Addison C

Simanis V

Rudge K

Philp R

Grimaldi M

Court W

Article Info

Journal

Oncogene

Abbr.

Oncogene

ISSN

0950-9232

Published

1990-06-00

Pages

795-81

Language

English

Region

England

NLM ID

8711562

Subset

External Links

PubMed source View journal details

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p53 interacts with p34cdc2 in mammalian cells: implications for cell cycle control and oncogenesis.

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