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PMID: 2142477 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Correlation between the V beta 4+ CD8+ T-cell population and the H-2d haplotype.

Immunogenetics ·Vol. 31 ·No. 5-6 ·1990-00-00 ·Pages 333-9

Tomonari K, Lovering E, Spencer S

Abstract

The V beta 4+ T-cell population was examined with a newly established antibody, KT4, specific for V beta 4. Between 4.8% and 19.4% of CD3+ peripheral T cells from various inbred strains of mice or F1 hybrids expressed V beta 4. The CD4 T-cell population had higher numbers of V beta 4+ T cells (5.5%-20.6%) than the CD8 T-cell population (2.5%-10.7%). Deletion of certain V beta-expressing T cells due to the presence of the Mlsa antigen and/or the absence of certain Tcrb-V genes increased relative numbers of V beta 4+ T cells. The data suggest that V beta 4+ CD8+ T cells might be positively selected by H-2d molecules.

MeSH Terms
Animals Antibodies, Monoclonal/biosynthesis Antibody Specificity Flow Cytometry H-2 Antigens/immunology Mice Mice, Inbred Strains Rats Receptors, Antigen, T-Cell/genetics,immunology Receptors, Antigen, T-Cell, alpha-beta Species Specificity T-Lymphocytes/immunology
Chemicals
Antibodies, Monoclonal H-2 Antigens Receptors, Antigen, T-Cell Receptors, Antigen, T-Cell, alpha-beta
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Tomonari K
Transplantation Biology Section, MRC Clinical Research Centre, Harrow, Middlesex, England.
Lovering E
Spencer S
References (48)
48 references, click to expand
  1. Expression of antigen-specific, major histocompatibility complex-restricted receptors by cortical and medullary thymocytes in situ.
    Cell. 1985 Dec;43(2 Pt 1):543-50 PMID: 3907858
  2. A rat antibody against a structure functionally related to the mouse T-cell receptor/T3 complex.
    Immunogenetics. 1988;28(6):455-8 PMID: 2972613
  3. The generation of mature T cells requires interaction of the alpha beta T-cell receptor with major histocompatibility antigens.
    Nature. 1989 Apr 13;338(6216):591-3 PMID: 2784545
  4. The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens.
    Nature. 1988 Oct 27;335(6193):796-801 PMID: 3263572
  5. The thymus has two functionally distinct populations of immature alpha beta + T cells: one population is deleted by ligation of alpha beta TCR.
    Cell. 1989 Sep 22;58(6):1047-54 PMID: 2673539
  6. T-cell receptor-specific monoclonal antibodies against a V beta 11-positive mouse T-cell clone.
    Immunogenetics. 1988;28(6):445-51 PMID: 2460404
  7. Positive selection of CD4+ thymocytes controlled by MHC class II gene products.
    Nature. 1988 Dec 1;336(6198):471-3 PMID: 3264054
  8. The major histocompatibility complex-restricted antigen receptor on T cells: distribution on thymus and peripheral T cells.
    Cell. 1984 Sep;38(2):577-84 PMID: 6331891
  9. Positive selection determines T cell receptor V beta 14 gene usage by CD8+ T cells.
    J Exp Med. 1989 Jul 1;170(1):135-43 PMID: 2501444
  10. Thymic selection process induced by hybrid antibodies.
    Nature. 1988 Dec 1;336(6198):473-5 PMID: 3057386
  11. Phenotypic differences between alpha beta versus beta T-cell receptor transgenic mice undergoing negative selection.
    Nature. 1989 Aug 17;340(6234):559-62 PMID: 2528070
  12. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules.
    Nature. 1988 Oct 20;335(6192):730-3 PMID: 3262831
  13. Tolerance in vivo and in vitro.
    Immunol Rev. 1990 Aug;116:139-57 PMID: 2227992
  14. In vivo helper activity of autoreactive T cell clones.
    J Immunol. 1985 Sep;135(3):1598-602 PMID: 3160771
  15. Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage.
    Nature. 1988 Aug 18;334(6183):620-3 PMID: 3261392
  16. Possible role of V beta T cell receptor genes in susceptibility to collagen-induced arthritis in mice.
    J Exp Med. 1988 Mar 1;167(3):832-9 PMID: 2965210
  17. Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes.
    Nature. 1988 Nov 3;336(6194):76-9 PMID: 3263575
  18. The role of the T-cell receptor in thymocyte maturation: effects in vivo of anti-receptor antibody.
    Proc Natl Acad Sci U S A. 1986 Nov;83(22):8728-32 PMID: 3095843
  19. Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex.
    Nature. 1988 Mar 3;332(6159):35-40 PMID: 3126396
  20. Down-regulation of the T cell receptor by a mitogenic anti-Thy-1 antibody.
    Eur J Immunol. 1988 Jan;18(1):179-82 PMID: 3257921
  21. Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy.
    Cell. 1988 Aug 12;54(4):577-92 PMID: 2456857
  22. An explanation for the protective effect of the MHC class II I-E molecule in murine diabetes.
    Nature. 1989 Sep 28;341(6240):326-8 PMID: 2507922
  23. A T cell receptor V beta segment that imparts reactivity to a class II major histocompatibility complex product.
    Cell. 1987 Apr 24;49(2):263-71 PMID: 3471350
  24. Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor.
    J Immunol. 1985 Jun;134(6):3994-4000 PMID: 2580901
  25. Two monoclonal antibodies specific for the T cell receptor V alpha 8.
    Eur J Immunol. 1989 Jun;19(6):1131-5 PMID: 2526741
  26. Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand.
    Cell. 1989 Sep 22;58(6):1035-46 PMID: 2476238
  27. H-T5 and H-T16, recognized by T-cell clones, are encoded by a gene(s) linked to Thy-1.2.
    Immunogenetics. 1987;26(4-5):313-4 PMID: 2888729
  28. The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype.
    J Exp Med. 1984 Aug 1;160(2):452-71 PMID: 6206178
  29. Predominant expression of a T cell receptor V beta gene subfamily in autoimmune encephalomyelitis.
    J Exp Med. 1988 May 1;167(5):1586-96 PMID: 2452856
  30. Rearrangement and transcription of the beta-chain genes of the T-cell antigen receptor in different types of murine lymphocytes.
    Nature. 1985 Feb 21-27;313(6004):647-53 PMID: 3156277
  31. Positive selection of CD4-CD8+ T cells in the thymus of normal mice.
    Nature. 1989 Mar 2;338(6210):76-8 PMID: 2521924
  32. Positive selection of CD4+ T cells mediated by MHC class II-bearing stromal cell in the thymic cortex.
    Nature. 1989 Oct 19;341(6243):649-51 PMID: 2571938
  33. Involvement of distinct murine T-cell receptors in the autoimmune encephalitogenic response to nested epitopes of myelin basic protein.
    Proc Natl Acad Sci U S A. 1988 Nov;85(22):8608-12 PMID: 2460872
  34. In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes.
    Cell. 1988 Mar 25;52(6):831-41 PMID: 3258191
  35. Expression and role of the T cell receptor in early thymocyte differentiation in vitro.
    J Immunol. 1987 Feb 15;138(4):999-1008 PMID: 3492547
  36. Positive selection of the T cell repertoire: where and when does it occur?
    Cell. 1989 Sep 22;58(6):1027-33 PMID: 2505933
  37. The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cells.
    J Exp Med. 1989 Apr 1;169(4):1405-19 PMID: 2538552
  38. Influence of the major histocompatibility complex on positive thymic selection of V beta 17a+ T cells.
    Science. 1989 Apr 14;244(4901):214-7 PMID: 2784868
  39. Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes.
    Nature. 1988 Jun 23;333(6175):742-6 PMID: 3260350
  40. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention.
    Cell. 1988 Jul 15;54(2):263-73 PMID: 2455603
  41. A third T-cell receptor beta-chain variable region gene encodes reactivity to Mls-1a gene products.
    Proc Natl Acad Sci U S A. 1989 Aug;86(16):6293-6 PMID: 2474831
  42. The murine T-cell receptor uses a limited repertoire of expressed V beta gene segments.
    Nature. 1985 Aug 8-14;316(6028):517-23 PMID: 2412120
  43. T cell tolerance by clonal elimination in the thymus.
    Cell. 1987 Apr 24;49(2):273-80 PMID: 3494522
  44. Antigen and MHC restriction specificity of two types of cloned male-specific T cell lines.
    J Immunol. 1983 Oct;131(4):1641-5 PMID: 6194209
  45. T-cell receptor expressed on an autoreactive T-cell clone, clone 4. I. Induction of various T-receptor functions by anti-T idiotypic antibodies.
    Cell Immunol. 1985 Nov;96(1):147-62 PMID: 3879721
  46. Positive and negative selection of an antigen receptor on T cells in transgenic mice.
    Nature. 1988 Nov 3;336(6194):73-6 PMID: 3263574
  47. T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens.
    Nature. 1988 Mar 3;332(6159):40-5 PMID: 3126397
  48. Thymic major histocompatibility complex antigens and the alpha beta T-cell receptor determine the CD4/CD8 phenotype of T cells.
    Nature. 1988 Sep 15;335(6187):229-33 PMID: 2970593
Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF02115007
Published
1990-00-00
Pages
333-9
Language
English
Region
United States
NLM ID
0420404
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02115007 View journal details
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